ArticleBiotechnology for biofuels2017
A design-build-test cycle using modeling and experiments reveals interdependencies between upper glycolysis and xylose uptake in recombinant
Article in Biotechnology for biofuels, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Bacteria as living biosensors for DNA.Nature reviews bioengineering · 2026Article
- Innovative tools for customized yeast cell factory.Biodesign research · 2025Article
- Coarse-Grained Modeling Elucidates Differential Metabolism ofACS synthetic biology · 2025Article
- Construction of an alternative NADPH regeneration pathway improves ethanol production inSynthetic and systems biotechnology · 2024Article
- Rational strain design with minimal phenotype perturbation.Nature communications · 2024Article
- Generative machine learning produces kinetic models that accurately characterize intracellular metabolic states.Nature catalysis · 2024Article
- Article
- Reconstructing Kinetic Models for Dynamical Studies of Metabolism using Generative Adversarial Networks.Nature machine intelligence · 2022Article
- The effects of model complexity and size on metabolic flux distribution and control: case study in Escherichia coli.BMC bioinformatics · 2021Article
- Transcription Analysis of RecombinantJournal of microbiology and biotechnology · 2020Article
- Large-scale kinetic metabolic models ofBiotechnology for biofuels · 2020Article
- Promoting the Synthesis of Precursor Substances by Overexpressing Hexokinase (Hxk) and Hydroxymethylglutaryl-CoA Synthase (Erg13) to Elevate β-Carotene Production in EngineeredFrontiers in microbiology · 2020Article
- Galactose to tagatose isomerization at moderate temperatures with high conversion and productivity.Nature communications · 2019Article
- Uncertainty reduction in biochemical kinetic models: Enforcing desired model properties.PLoS computational biology · 2019Article
- pyTFA and matTFA: a Python package and a Matlab toolbox for Thermodynamics-based Flux Analysis.Bioinformatics (Oxford, England) · 2019Article
- Defining informative priors for ensemble modeling in systems biology.Nature protocols · 2018Article
- Laboratory evolution for forced glucose-xylose co-consumption enables identification of mutations that improve mixed-sugar fermentation by xylose-fermenting Saccharomyces cerevisiae.FEMS yeast research · 2018Article
- Association of improved oxidative stress tolerance and alleviation of glucose repression with superior xylose-utilization capability by a natural isolate ofBiotechnology for biofuels · 2018Article
- Strategies to ImproveIndian journal of microbiology · 2017Review
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent advancements in omics measurement technologies have led to an ever-increasing amount of available experimental data that necessitate systems-oriented methodologies for efficient and systematic integration of data into consistent large-scale kinetic models. These models can help us to uncover new insights into cellular physiology and also to assist in the rational design of bioreactor or fermentation processes. Optimization and Risk Analysis of Complex Living Entities (ORACLE) framework for the construction of large-scale kinetic models can be used as guidance for formulating alternative metabolic engineering strategies.
resultsWe used ORACLE in a metabolic engineering problem: improvement of the xylose uptake rate during mixed glucose-xylose consumption in a recombinant
conclusionsWe present a design-build-test cycle composed of modeling efforts and experiments with a glucose-xylose co-utilizing recombinant
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