ReviewFrontiers in endocrinology2017
Desynchronization of Circadian Clocks in Cancer: A Metabolic and Epigenetic Connection.
Review in Frontiers in endocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Circadian rhythm related genes identified through tumorigenesis and immune infiltration-guided strategies as predictors of prognosis, immunotherapy response, and candidate drugs in skin cutaneous malignant melanoma.Frontiers in immunology · 2025Article
- Effects of glyphosate exposure on the miRNA expression profile and construction of the miRNA-mRNA regulatory network in mouse bone marrow cells.Functional & integrative genomics · 2022Article
- Prevalence of Sleep Disturbances in Pediatric Cancer Patients and Their Diagnosis and Management.Children (Basel, Switzerland) · 2021Review
- New Insights Into Cancer Chronotherapies.Frontiers in pharmacology · 2021Review
- Exposure to Air Pollution Disrupts Circadian Rhythm through Alterations in Chromatin Dynamics.iScience · 2020Article
- Metabolic effects of air pollution exposure and reversibility.The Journal of clinical investigation · 2020Article
- The interaction of the circadian and immune system: Desynchrony as a pathological outcome to traumatic brain injury.Neurobiology of sleep and circadian rhythms · 2020Review
- Tracking leukemic T-cell transcriptional dynamics in vivo with a blood-based reporter assay.FEBS open bio · 2020Article
- Stromal Expression of the Core Clock GeneFrontiers in cell and developmental biology · 2020Article
- Magnetic fields, cancer and circadian rhythms: hypotheses on the relevance of intermittence and cycling.Proceedings. Biological sciences · 2019Article
- It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.The Yale journal of biology and medicine · 2019Review
- Circadian rhythms in the three-dimensional genome: implications of chromatin interactions for cyclic transcription.Clinical epigenetics · 2019Review
- An Overview of the Polymorphisms of Circadian Genes Associated With Endocrine Cancer.Frontiers in endocrinology · 2019Review
- A Novel Loop: Mutual Regulation Between Epigenetic Modification and the Circadian Clock.Frontiers in plant science · 2019Review
- More than a powerplant: the influence of mitochondrial transfer on the epigenome.Current opinion in physiology · 2018Article
- Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks.International journal of molecular sciences · 2018Article
- Microcystin-LR regulates circadian clock and antioxidant gene expression in cultured rat cardiomyocytes.Cellular & molecular biology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian clocks are innate oscillators that drive daily rhythms in metabolism, physiology, and behavior. 24-h rhythms in gene expression, driven by core clock transcription factors, reflect the epigenetic state of the cell, which in turn is dictated by the metabolic environment. Cancer cells alter their metabolic state and gene expression and therefore are likely to tweak circadian clock function in their favor. Over the past decade, we have witnessed an extraordinary increase in systems-level studies that suggest intricate mechanistic links between the cellular metabolome and the circadian epigenome. In parallel, reprogramming of cellular clock function in cancers is increasingly evident and the role of clock genes in the development of hematological tumors, as well as their pathophysiological effects on tissues distal to the tumor, has been described. Furthermore, the interplay between components of the circadian clock, metabolic enzymes, and oncogenes is starting to be better understood, such as the close association between overexpression of the Myc oncogene and perturbation of circadian and metabolic rhythms, thus opening new avenues to treat cancers. This review article explores current knowledge on the circadian metabolome and the molecular pathways they control, with a focus on their involvement in the development of hematopoietic malignancies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.