Evidence map›Paper›PMID 28674487›Full record

ArticleFrontiers in neural circuits2017

Pyramidal Neurons in Different Cortical Layers Exhibit Distinct Dynamics and Plasticity of Apical Dendritic Spines.

Michelle Tjia, Xinzhu Yu, Lavpreet S Jammu, Ju Lu, Yi Zuo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
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  5. Cortical Somatostatin Innervation Follows a Unique Experience-Independent Developmental Trajectory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Article
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  9. Article
  10. Article
  11. H-Ras induces exuberantiScience · 2024
    Article
  12. Review
  13. Divergent Learning-Related Transcriptional States of Cortical Glutamatergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  14. Article
  15. Review
  16. Article
  17. Introduction: What Are Dendritic Spines?Advances in neurobiology · 2023
    Article
  18. Article
  19. Article
  20. Synaptic modifications in learning and memory - A dendritic spine story.Seminars in cell & developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michelle TjiaDepartment of Molecular, Cell and Developmental Biology, University of CaliforniaSanta Cruz, CA, United States.
Xinzhu YuDepartment of Molecular, Cell and Developmental Biology, University of CaliforniaSanta Cruz, CA, United States.
Lavpreet S JammuDepartment of Molecular, Cell and Developmental Biology, University of CaliforniaSanta Cruz, CA, United States.
Ju LuDepartment of Molecular, Cell and Developmental Biology, University of CaliforniaSanta Cruz, CA, United States.
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of CaliforniaSanta Cruz, CA, United States.
University of California, Santa Cruz · US

Funding

Dynamics and molecular mechanism of synaptic connectivity change during learningR01MH104227 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2014 to 2018
$2.1M
Contribution of astrocytes to the Fragile X SyndromeR01MH109475 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2016 to 2020
$2.0M
Neurovascular Mechanisms of Time-Dependencies in Stroke RehabilitationR01NS078791 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K, JONES, THERESA A · 2012 to 2016
$1.7M
Development of synaptic abnormality in fragile X miceR01MH094449 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2012 to 2015
$1.5M
NIMH NIH HHS R01 MH094449NIMH NIH HHS R01 MH104227NIMH NIH HHS R01 MH109475NINDS NIH HHS R01 NS078791
6 · The paper itself

Abstract

The mammalian cerebral cortex is typically organized in six layers containing multiple types of neurons, with pyramidal neurons (PNs) being the most abundant. PNs in different cortical layers have distinct morphology, physiology and functional roles in neural circuits. Therefore, their development and synaptic plasticity may also differ. Using

Indexed as

Age FactorsAnimalsBacterial ProteinsCerebral CortexDendritesDendritic SpinesDiscrimination, PsychologicalElectroporationFemaleLuminescent ProteinsMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ConfocalMotor SkillsBacterial ProteinsLuminescent Proteinsyellow fluorescent protein, Bacteriadendritic spinesin vivo imagingmotor-skill learningsensory deprivationspine plasticity

Identifiers

PMID28674487
PMCPMC5474458
OpenAlexW2627036977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.