ArticleInternational journal of obesity (2005)2017
A high salt diet inhibits obesity and delays puberty in the female rat.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Gut dysbiosis induced by a high-salt diet aggravates atherosclerosis by increasing the absorption of saturated fatty acids in ApoE-deficient mice.Journal of clinical biochemistry and nutrition · 2025Article
- Differential bone metabolism and protein expression in mice fed a high-fat diet versus Daurian ground squirrels following natural pre-hibernation fattening.Journal of Zhejiang University. Science. B · 2022Article
- Amoxicillin impact on pathophysiology induced by short term high salt diet in mice.Scientific reports · 2022Article
- Effects of sea salt intake on metabolites, steroid hormones, and gut microbiota in rats.PloS one · 2022Article
- Analysis of sex differences in dietary copper-fructose interaction-induced alterations of gut microbial activity in relation to hepatic steatosis.Biology of sex differences · 2021Article
- Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury.Frontiers in immunology · 2021Article
- Consumption of salt leads to ameliorate symptoms of metabolic disorder and change of gut microbiota.European journal of nutrition · 2020Article
- The physiological and molecular mechanisms to maintain water and salt homeostasis in response to high salt intake in Mongolian gerbils (Meriones unguiculatus).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2020Article
- High-fat diet alters fluid intake without reducing sensitivity to glucagon-like peptide-1 receptor agonist effects.Physiology & behavior · 2020Article
- Article
- High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
objectivesProcessed foods are considered major contributors to the worldwide obesity epidemic. In addition to high sugar and fat contents, processed foods contain large amounts of salt. Owing to the correlations with rising adiposity, salt has recently been proposed to be obesogenic. This study investigated three hypotheses: (i) high salt contributes to weight gain and adiposity in juvenile female rats, (ii) puberty onset would be altered because salt is known to affect neuronal systems involved in activating the reproductive system, and (iii) enhanced adiposity will act synergistically with salt to drive early puberty onset.
designFemale weanling rats (post-natal day 21, n=105) were fed a low fat/low salt diet, low fat/high salt diet, high fat/low salt diet or a high salt/high fat diet for 24 days. Metabolic measures, including weight gain, food intake, fecal output, activity and temperature were recorded in subsets of animals.
resultsBody weight, retroperitoneal and perirenal fat pad weight, and adipocyte size were all lower in animals fed high fat/high salt compared with animals fed high fat alone. Leptin levels were reduced in high fat/high salt fed animals compared with high fat/low salt-fed animals. Daily calorie intake was higher initially but declined with adjusted food intake and was not different among groups after 5 days. Osmolality and corticosterone were not different among groups. Fecal analysis showed excess fat excretion and a decreased digestive efficiency in animals fed high fat/low salt but not in animals fed high fat/high salt. Although respiratory exchange ratio was reduced by high dietary fat or salt, aerobic-resting metabolic rate was not affected by the diet. High salt delayed puberty onset, regardless of dietary fat content.
conclusionsSalt delays puberty and prevents the obesogenic effect of a high fat diet. The reduced weight gain evident in high salt-fed animals is not due to differences in food intake or digestive efficiency.
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