ArticleScientific reports2017
9-cis retinoic acid induces neurorepair in stroke brain.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Targeted blood-brain barrier penetration for traumatic brain injury therapy via RXR/PPAR-driven microglial M2 polarization.Materials today. Bio · 2026Article
- Neuroprotective effects of psilocybin in a rat model of stroke.BMC neuroscience · 2024Article
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- Association of CYP26C1 Promoter Hypomethylation with Small Vessel Occlusion in Korean Subjects.Genes · 2021Article
- Retinoids as Chemo-Preventive and Molecular-Targeted Anti-Cancer Therapies.International journal of molecular sciences · 2021Review
- Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation.Pharmaceutics · 2020Review
- Administration of all-trans retinoic acid after experimental traumatic brain injury is brain protective.British journal of pharmacology · 2020Article
- Human Milk Oligosaccharide 2'-Fucosyllactose Reduces Neurodegeneration in Stroke Brain.Translational stroke research · 2020Article
- Article
- Decreased Serum Retinoic Acid May Predict Poor Outcome in Ischemic Stroke Patients.Neuropsychiatric disease and treatment · 2020Article
- Repetitive mild traumatic brain injury alters diurnal locomotor activity and response to the light change in mice.Scientific reports · 2019Article
- Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats.Journal of neuroinflammation · 2019Article
- Scavenger Receptor Class B type 1 (SR-B1) and the modifiable risk factors of stroke.Chinese neurosurgical journal · 2019Review
- The Effect of Melatonin on Locomotor Behavior and Muscle Physiology in the Sea CucumberFrontiers in physiology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The purpose of this study was to examine the neurorestorative effect of delayed 9 cis retinoic acid (9cRA) treatment for stroke. Adult male rats received a 90-min right distal middle cerebral artery occlusion (dMCAo). Animals were separated into two groups with similar infarction sizes, based on magnetic resonance imaging on day 2 after dMCAo. 9cRA or vehicle was given via an intranasal route daily starting from day 3. Stroke rats receiving 9cRA post-treatment showed an increase in brain 9cRA levels and greater recovery in motor function. 9cRA enhanced the proliferation of bromodeoxyuridine (+) cells in the subventricular zone (SVZ) and lesioned cortex in the stroke brain. Using subventricular neurosphere and matrigel cultures, we demonstrated that proliferation and migration of SVZ neuroprogenitor cells were enhanced by 9cRA. Our data support a delayed and non-invasive drug therapy for stroke. Intranasal 9cRA can facilitate the functional recovery and endogenous repair in the ischemic brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.