Evidence map›Paper›PMID 28674410›Full record

ArticleScientific reports2017

Mobile nucleic acid amplification testing (mobiNAAT) for Chlamydia trachomatis screening in hospital emergency department settings.

D J Shin, P Athamanolap, L Chen, J Hardick, M Lewis, Y H Hsieh, R E Rothman, C A Gaydos, T H Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 69 citations in OpenAlex.

  1. Current and Emerging Approaches and Technologies for Rapid Detection of Neisseria gonorrhoeae Antimicrobial Resistance.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Thermally Responsive Alkane Partitions for Assay Automation.ACS applied materials & interfaces · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

D J ShinDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
P AthamanolapDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
L ChenDepartment of Mechanical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA.
J HardickDivision of Infectious Diseases, School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA.
M LewisDepartment of Emergency Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA.
Y H HsiehDepartment of Emergency Medicine, School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA.
R E RothmanDivision of Infectious Diseases, School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA.
C A GaydosDivision of Infectious Diseases, School of Medicine, The Johns Hopkins University, Baltimore, MD, 21218, USA.
T H WangDepartment of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, 21218, USA. thwang@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Yukari C Manabe · 2007 to 2026
$34.6M
A Droplet-based single cell platform for pathogen identification and ASTR01AI117032 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LIAO, JOSEPH C, WANG, TZA-HUEI JEFF · 2015 to 2019
$5.7M
NIAID NIH HHS R01 AI117032NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

Management of curable sexually-transmitted infections (STI) such as Chlamydia can be revolutionized by highly sensitive nucleic acid testing that is deployable at the point-of-care (POC). Here we report the development of a mobile nucleic acid amplification testing (mobiNAAT) platform utilizing a mobile phone and droplet magnetofluidics to deliver NAAT in a portable and accessible format. By using magnetic particles as a mobile substrate for nucleic acid capture and transport, fluid handling is reduced to particle translocation on a simple magnetofluidic cartridge assembled with reagents for nucleic acid purification and amplification. A mobile phone user interface operating in tandem with a portable Bluetooth-enabled cartridge-processing unit facilitates process integration. We tested 30 potentially Chlamydia trachomatis (CT)-infected patients in a hospital emergency department and confirmed that mobiNAAT showed 100% concordance with laboratory-based NAAT. Concurrent evaluation by a nontechnical study coordinator who received brief training via an embedded mobile app module demonstrated ease of use and reproducibility of the platform. This work demonstrates the potential of mobile nucleic acid testing in bridging the diagnostic gap between centralized laboratories and hospital emergency departments.

Indexed as

Nucleic Acid Amplification TechniquesChlamydia InfectionsChlamydia trachomatisEmergency Service, HospitalFemaleHumansMalePoint-of-Care SystemsSensitivity and SpecificityWorkflow

Identifiers

PMID28674410
PMCPMC5495747
OpenAlexW2695613910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.