Evidence map›Paper›PMID 28674324›Full record

ReviewJournal of atherosclerosis and thrombosis2017

Flow Mediated Dilatation as a Biomarker in Vascular Surgery Research.

Kirthi Bellamkonda, Matthew Williams, Ashok Handa, Regent Lee

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of atherosclerosis and thrombosis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05951894 (Flow-mediated Arterial Dilatation, Hypertension, Endothelin-1), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05951894 completednot on this mapstarted 2023, after this paper: background citation

Flow-mediated Arterial Dilatation, Hypertension, Endothelin-1 (ET-1) and Soluble Intercellular Adhesion Molecule (sICAM-1) in Obese Adolescents

Typeobservational_patient_registrySponsorUniversitas AirlanggaRan2023 to 2023Enrolled70ConditionsObesity, Hypertension, Adolescent Obesity
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Impaired vascular reactivity in sepsis - a systematic review with meta-analysis.Archives of medical sciences. Atherosclerotic diseases · 2019
    Article
  10. Hypertension in Thyroid Disorders.Frontiers in endocrinology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kirthi BellamkondaNuffield Department of Surgical Sciences, University of Oxford.
Matthew WilliamsNuffield Department of Surgical Sciences, University of Oxford.
Ashok HandaNuffield Department of Surgical Sciences, University of Oxford.
Regent LeeNuffield Department of Surgical Sciences, University of Oxford.
University of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial dysfunction is one of the hallmarks of atherogenesis, and correlates with many cardiovascular risk factors. One of the features of endothelial dysfunction is the loss of nitric oxide (NO) bioavailability, resulting in derangements in the vasodilatory response of the vessel wall. Flow mediated dilatation (FMD) of the brachial artery is an accepted method for non-invasive assessment of systemic endothelial function. FMD is examined extensively in the context of cardiovascular research, and has been utilised as a routine assessment in large cohorts such as the Framingham Heart Study, Young Finns Study, and Gutenberg Heart Study. However, FMD is less known in the context of vascular surgery research, despite the similarities between the underpinning disease mechanisms. This review will provide a summary of FMD in terms of its history of development and the conduct of the test in research settings. It will further highlight the key literature of FMD as a biomarker for vascular surgeons, particularly in the context of abdominal aortic aneurysms and lower limb peripheral arterial disease.

Indexed as

BiomarkersCardiovascular DiseasesDilatationEndothelium, VascularHumansRegional Blood FlowVasodilationBiomarkersAbdominal aortic aneurysmBiomarkersFlow mediated dilatationPeripheral arterial disease

Identifiers

PMID28674324
PMCPMC5556184
OpenAlexW2725048269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.