ArticleBMJ open2017
Effect of adherence to antihypertensive medication on stroke incidence in patients with hypertension: a population-based retrospective cohort study.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Incidence and predictors of stroke among hypertension patients in Awi Zone public hospitals, Northwest Ethiopia: Retrospective follow-up study.BMC cardiovascular disorders · 2026Article
- Fixed-dose combination antihypertensive therapy and healthcare utilization in U.S. adults with hypertension: a propensity score-based analysis of a nationally representative population.Frontiers in pharmacology · 2026Article
- Adherence to perindopril/amlodipine/atorvastatin combination according to the administration strategy.European heart journal. Quality of care & clinical outcomes · 2025Article
- Prevalence of Reported Dietary Supplement Use in 2019 Older Adult (≥ 55 Years) National Alzheimer's Coordinating Center Participants With Normal Cognition, Mild Cognitive Impairment or Dementia.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Modifiable Risk Factors for Stroke in Syria: A Nationwide Multi-centre Case-Control Study.Scientific reports · 2025Article
- Factors Associated with Medication Compliance among Hypertensive Patients in Barangay Sambag II, Cebu City.Acta medica Philippina · 2025Article
- Adherence to antihypertensive medications and associated factors in patients with hypertension, Oromia, Ethiopia: a multicenter study.Scientific reports · 2024Article
- Antihypertensive Medication Adherence and Medical Costs, Health Care Use, and Labor Productivity Among People With Hypertension.Journal of the American Heart Association · 2024Article
- Determinants of adherence to post-stroke/transient ischemic attack secondary prevention medications: A cohort study.European journal of neurology · 2024Article
- Disability Status and Secondary Prevention Among Survivors of Stroke: A Cross-Sectional Analysis of the 2011 to 2018 National Health and Nutrition Examination Survey.Journal of the American Heart Association · 2023Article
- Development and validation of a medication non-adherence scale for Malaysian hypertensive patients: a mixed-methods study.Environmental health and preventive medicine · 2023Article
- Clinical and epidemiological implications of the data on the Korean clinical hypertension cohort.The Korean journal of internal medicine · 2023Article
- Multiprofessional intervention to improve adherence to medication in stroke patients: a study protocol for a randomised controlled trial (ADMED AVC study).European journal of hospital pharmacy : science and practice · 2022Article
- Adherence to Treatment and Level of Satisfaction Among Saudi Hypertensive Patients: A Multi-City Study.Cureus · 2021Article
- Implementation of a Real-Time Medication Intake Monitoring Technology Intervention in Community Pharmacy Settings: A Mixed-Method Pilot Study.Pharmacy (Basel, Switzerland) · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Incidence Hypertension and Fasting Blood Glucose from Real-World Data: Retrospective Cohort for 7-Years Follow-Up.International journal of environmental research and public health · 2021Article
- Nonadherence to Self-Care Practices, Antihypertensive Medications, and Associated Factors among Hypertensive Patients in a Follow-up Clinic at Asella Referral and Teaching Hospital, Ethiopia: A Cross-Sectional Study.International journal of hypertension · 2021Article
- Self-Care Practice and Associated Factors among Hypertensive Patients in Ethiopia: A Systematic Review and Meta-Analysis.International journal of hypertension · 2021Article
- Association of health-related private transfers with treatment compliance of musculoskeletal disorders in the rural elderly: evidence from an underdeveloped region of China.BMC musculoskeletal disorders · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh blood pressure is a modifiable risk factor for stroke, but non-adherence to antihypertensive medication is a growing concern for healthcare providers in controlling blood pressure. This study aimed to investigate the effect of adherence to antihypertensive medication on stroke incidence.
designRetrospective cohort study.
settingWe analysed National Health Insurance claim data and check-up data from 2009 to 2013.
participants38520patients with hypertension were defined as those diagnosed with hypertension and prescribed antihypertensive medication.
interventionsNo interventions were made. OUTCOME MEASURE: Poisson regression analysis using generalised estimating equations models was performed to examine the association between adherence to antihypertensive medication and stroke incidence.
resultsAmong 38 520 patients with hypertension, 957 (2.5%) strokes occurred during the study period. Non-adherence to medication was significantly associated with a higher risk of stroke (intermediate adherence: adjusted relative risk (aRR)=1.13, 95% CI=1.06 to 1.21; poor adherence: aRR=1.27, 95% CI=1.17 to 1.38).
conclusionsNon-adherence to antihypertensive medication in patients with hypertension was associated with an increased risk of stroke. Therefore, healthcare providers need to focus on interventional strategies to ensure that these patients adhere to medication therapy and to provide continuing support to achieve long-term adherence, ultimately minimising negative health outcomes.
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