Evidence map›Paper›PMID 28674061›Full record

Trial reportAntimicrobial agents and chemotherapy2017

Assessment of Clinical Pharmacokinetic Drug-Drug Interaction of Antimalarial Drugs α/β-Arteether and Sulfadoxine-Pyrimethamine.

Y S Chhonker, V V Bhosale, S K Sonkar, H Chandasana, D Kumar, S Vaish, S C Choudhary, S Bhadhuria, S Sharma, R K Singh and 4 more

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Y S ChhonkerPharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
V V BhosaleClinical and Experiment Division, CSIR-Central Drug Research Institute, Lucknow, India drvivekbhosale@cdri.res.in rabi_bhatta@cdri.res.in.
S K SonkarCPU, Department of Medicine, King George's Medical University, Lucknow, India.
H ChandasanaPharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
D KumarPharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
S VaishCPU, Department of Medicine, King George's Medical University, Lucknow, India.
S C ChoudharyCPU, Department of Medicine, King George's Medical University, Lucknow, India.
S BhadhuriaToxicology Division, CSIR-Central Drug Research Institute, Lucknow, India.
S SharmaToxicology Division, CSIR-Central Drug Research Institute, Lucknow, India.
R K SinghToxicology Division, CSIR-Central Drug Research Institute, Lucknow, India.
G K JainPharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India.
A K VaishCPU, Department of Medicine, King George's Medical University, Lucknow, India.
S P S GaurClinical and Experiment Division, CSIR-Central Drug Research Institute, Lucknow, India.
R S BhattaPharmacokinetics & Metabolism Division, CSIR-Central Drug Research Institute, Lucknow, India drvivekbhosale@cdri.res.in rabi_bhatta@cdri.res.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimalarial drug combination therapy is now being widely used for the treatment of uncomplicated malaria. The objective of the present study was to investigate the effects of coadministration of intramuscular α/β-arteether (α/β-AE) and oral sulfadoxine-pyrimethamine (SP) on the pharmacokinetic properties of each drug as a drug-drug interaction study to support the development of a fixed-dose combination therapy. A single-dose, open-label, crossover clinical trial was conducted in healthy adult Indian male volunteers (18 to 45 years,

Indexed as

AdolescentAdultAntimalarialsArtemisininsChromatography, LiquidDrug CombinationsDrug InteractionsHealthy VolunteersHumansMalaria, FalciparumMaleMiddle AgedPlasmodium falciparumPyrimethamineSulfadoxineTandem Mass SpectrometryAntimalarialsArtemisininsartemotilDrug Combinationsfanasil, pyrimethamine drug combinationPyrimethamineSulfadoxinecombination therapymalariapharmacokineticspyrimethaminesulfadoxineα/β-arteether

Identifiers

PMID28674061
PMCPMC5571326

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.