Evidence map›Paper›PMID 28674030›Full record

ArticleInfection and immunity2017

Robyn E Elphinstone, Rickvinder Besla, Eric A Shikatani, Ziyue Lu, Alfred Hausladen, Matthew Davies, Clinton S Robbins, Mansoor Husain, Jonathan S Stamler, Kevin C Kain

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Robyn E ElphinstoneSandra Rotman Centre for Global Health, University Health Network, University of Toronto, Toronto, ON, Canada.
Rickvinder BeslaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Eric A ShikataniDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Ziyue LuSandra Rotman Centre for Global Health, University Health Network, University of Toronto, Toronto, ON, Canada.
Alfred HausladenInstitute of Transformative Molecular Medicine, Harrington Discovery Institute, Case Western Reserve University and University Hospitals, Cleveland, Ohio, USA.
Matthew DaviesSandra Rotman Centre for Global Health, University Health Network, University of Toronto, Toronto, ON, Canada.
Clinton S RobbinsDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Mansoor HusainDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.
Jonathan S StamlerInstitute of Transformative Molecular Medicine, Harrington Discovery Institute, Case Western Reserve University and University Hospitals, Cleveland, Ohio, USA.
Kevin C KainSandra Rotman Centre for Global Health, University Health Network, University of Toronto, Toronto, ON, Canada kevin.kain@uhn.ca.
University Health Network · CAUniversity of Toronto · CADiscovery Institute · US

Funding

Regulation of Beta-Adrenergic Receptor Signaling by S-NitrosylationP01HL075443 · NHLBI · DUKE UNIVERSITY · PI STAMLER, JONATHAN S. · 2004 to 2019
$26.1M
Identification of Novel DenitrosylasesR01GM099921 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI STAMLER, JONATHAN S. · 2013 to 2016
$1.4M
CIHR FDN-148439CIHR MOP-115160CIHR MOP-136813CIHR MOP-13721NHLBI NIH HHS P01 HL075443NIGMS NIH HHS R01 GM099921
6 · The paper itself

Abstract

Artesunate remains the mainstay of treatment for cerebral malaria, but it is less effective in later stages of disease when the host inflammatory response and blood-brain barrier integrity dictate clinical outcomes. Nitric oxide (NO) is an important regulator of inflammation and microvascular integrity, and impaired NO bioactivity is associated with fatal outcomes in malaria. Endogenous NO bioactivity in mammals is largely mediated by

Indexed as

Alcohol DehydrogenaseAnimalsAntimalarialsArtemisininsArtesunateDisease Models, AnimalFemaleMalaria, CerebralMaleMice, Inbred C57BLMice, KnockoutNitric OxidePlasmodium bergheiSurvival AnalysisT-LymphocytesTreatment OutcomeAdh5 protein, mouseAlcohol DehydrogenaseAntimalarialsArtemisininsArtesunateNitric Oxideexperimental cerebral malariaPlasmodium berghei ANKAS-nitrosoglutathione reductaseS-nitrosothiolsS-nitrosylation

Identifiers

PMID28674030
PMCPMC5563579
OpenAlexW2728511876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.