Evidence map›Paper›PMID 28674003›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.

Adam D Hargreaves, Long Zhou, Josef Christensen, Ferdinand Marlétaz, Shiping Liu, Fang Li, Peter Gildsig Jansen, Enrico Spiga, Matilde Thye Hansen, Signe Vendelbo Horn Pedersen and 8 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Why sequence the genome of every species? A view from evolutionary biology.Journal of the Marine Biological Association of the United Kingdom. Marine Biological Association of the United Kingdom · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Runaway GC Evolution in Gerbil Genomes.Molecular biology and evolution · 2020
    Article
  12. Article
  13. Article
  14. Generation of Gene-Knockout Mongolian Gerbils via CRISPR/Cas9 System.Frontiers in bioengineering and biotechnology · 2020
    Article
  15. Review
  16. Article
  17. A high-density genetic map and molecular sex-typing assay for gerbils.Mammalian genome : official journal of the International Mammalian Genome Society · 2019
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 5 countries.

Adam D HargreavesDepartment of Zoology, University of Oxford, Oxford, OX1 3PS, United Kingdom.
Long ZhouChina National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China.
Josef ChristensenNovo Nordisk, Måløv, DK-2760, Denmark.
Ferdinand MarlétazDepartment of Zoology, University of Oxford, Oxford, OX1 3PS, United Kingdom.ORCID 0000-0001-8124-4266
Shiping LiuChina National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China.
Fang LiChina National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China.
Peter Gildsig JansenNovo Nordisk, Måløv, DK-2760, Denmark.
Enrico SpigaFrancis Crick Institute, London, NW1 1AT, United Kingdom.
Matilde Thye HansenNovo Nordisk, Måløv, DK-2760, Denmark.
Signe Vendelbo Horn PedersenNovo Nordisk, Måløv, DK-2760, Denmark.
Shameek BiswasNovo Nordisk Research Centre, Seattle, WA 98109.
Kyle SerikawaNovo Nordisk Research Centre, Seattle, WA 98109.
Brian A FoxNovo Nordisk Research Centre, Seattle, WA 98109.
William R TaylorFrancis Crick Institute, London, NW1 1AT, United Kingdom.
John Frederick MulleySchool of Biological Sciences, Bangor University, Bangor, LL57 2DG, United Kingdom.ORCID 0000-0002-1537-7316
Guojie ZhangChina National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China; peter.holland@zoo.ox.ac.uk zhanggj@genomics.cn richardscottheller@gmail.com.
R Scott HellerNovo Nordisk, Måløv, DK-2760, Denmark; peter.holland@zoo.ox.ac.uk zhanggj@genomics.cn richardscottheller@gmail.com.
Peter W H HollandDepartment of Zoology, University of Oxford, Oxford, OX1 3PS, United Kingdom; peter.holland@zoo.ox.ac.uk zhanggj@genomics.cn richardscottheller@gmail.com.ORCID 0000-0003-1533-9376
Novo Nordisk (Denmark) · DKChina National GeneBank · CNNovo Nordisk (United States) · USThe Francis Crick Institute · GBUniversity of Oxford · GBBangor University · GBOkinawa Institute of Science and Technology Graduate University · JPUniversity of Copenhagen · DK

Funding

Cancer Research UKEuropean Research Council 268513Medical Research CouncilWellcome Trust FC001179
6 · The paper itself

Abstract

The sand rat

Indexed as

MutationSequence Analysis, DNATranscriptional ActivationAdaptation, BiologicalAnimalsChromosome MappingDiabetes Mellitus, Type 2EcosystemEvolution, MolecularGenes, HomeoboxGenomeGerbillinaeHomeodomain ProteinsInsulinMaleMultigene FamilyHomeodomain ProteinsInsulinpancreatic and duodenal homeobox 1 proteinTrans-Activatorsdesert rodentgene conversionhomeoboxPdx1type 2 diabetes

Identifiers

PMID28674003
PMCPMC5530673
OpenAlexW2726879832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.