Evidence map›Paper›PMID 28673978›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Unearthing a sesterterpene biosynthetic repertoire in the Brassicaceae through genome mining reveals convergent evolution.

Ancheng C Huang, Satria A Kautsar, Young J Hong, Marnix H Medema, Andrew D Bond, Dean J Tantillo, Anne Osbourn

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 129 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Genome-Wide Analysis of Oxidosqualene Cyclase Genes inCurrent issues in molecular biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A terpenoids database with the chemical content as a novel agronomic trait.Database : the journal of biological databases and curation · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Functional Prediction ofInternational journal of molecular sciences · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Ancheng C HuangDepartment of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom.
Satria A KautsarBioinformatics Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Young J HongDepartment of Chemistry, University of California, Davis, CA 95616.
Marnix H MedemaBioinformatics Group, Wageningen University, 6708 PB Wageningen, The Netherlands.
Andrew D BondDepartment of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Dean J TantilloDepartment of Chemistry, University of California, Davis, CA 95616.
Anne OsbournDepartment of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom; anne.osbourn@jic.ac.uk.
University of California, Davis · USWageningen University & Research · NLJohn Innes Centre · GBNorwich Research Park · GBUniversity of Cambridge · GB

Funding

An integrated pipeline for accelerated plant natural product discoveryU01GM110699 · NIGMS · STANFORD UNIVERSITY · PI SMOLKE, CHRISTINA D · 2015 to 2019
$4.5M
Biotechnology and Biological Sciences Research Council BB/J004561/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000614Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790NIGMS NIH HHS U01 GM110699
6 · The paper itself

Abstract

Sesterterpenoids are a rare terpene class harboring untapped chemodiversity and bioactivities. Their structural diversity originates primarily from the scaffold-generating sesterterpene synthases (STSs). In fungi, all six known STSs are bifunctional, containing C-terminal

Indexed as

Genome, PlantAlgorithmsAlkyl and Aryl TransferasesArabidopsis ProteinsBrassicaceaeDimethylallyltranstransferaseEvolution, MolecularMutationNicotianaPhylogenyPlant ProteinsPlants, Genetically ModifiedSesterterpenesAlkyl and Aryl TransferasesArabidopsis ProteinsDimethylallyltranstransferasePlant ProteinsSesterterpenesterpene synthaseBrassicaceaeconvergent evolutioncyclization mechanismplant natural productssesterterpene biosynthesis

Identifiers

PMID28673978
PMCPMC5530694
OpenAlexW2731067126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.