ArticleThe EMBO journal2017
Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells.
Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Apoptotic Cancer Cell-Primed Cancer-Associated Fibroblasts Suppress Immunosuppressive Macrophages via WISP-1-Integrin α5β3-STAT1 Signaling in Lung Cancer.International journal of biological sciences · 2026Article
- Pro-inflammatory effects of endogenous and recombinant MDA-7/IL-24 with RGD peptide on human hepatic stellate cells.Scientific reports · 2025Article
- Suppression of thrombospondin-1-mediated inflammaging prolongs hematopoietic health span.Science immunology · 2025Article
- CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal.Blood advances · 2024Article
- Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals.EMBO reports · 2023Article
- Identification and Characterization of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Inhibition of SRC-mediated integrin signaling in bone marrow niche enhances hematopoietic stem cell function.iScience · 2022Article
- ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration.The EMBO journal · 2022Article
- The extracellular matrix of hematopoietic stem cell niches.Advanced drug delivery reviews · 2022Review
- Regulation of emergency granulopoiesis during infection.Frontiers in immunology · 2022Review
- Review
- Niche-Mediated Integrin Signaling Supports Steady-State Hematopoiesis in the Spleen.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Yin and Yang: The dual effects of interferons on hematopoiesis.Experimental hematology · 2021Review
- Evaluation of the human type 3 adenoviral dodecahedron as a vector to target acute myeloid leukemia.Molecular therapy. Methods & clinical development · 2021Article
- Interferon Gamma Mediates Hematopoietic Stem Cell Activation and Niche Relocalization through BST2.Cell reports · 2020Article
- The Periostin/Integrin-αv Axis Regulates the Size of Hematopoietic Stem Cell Pool in the Fetal Liver.Stem cell reports · 2020Article
- Leukemia Stem Cell Release From the Stem Cell Niche to Treat Acute Myeloid Leukemia.Frontiers in cell and developmental biology · 2020Review
- Regulation of the Bone Marrow Niche by Inflammation.Frontiers in immunology · 2020Review
- αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- CaThe Journal of experimental medicine · 2018Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoietic homeostasis depends on the maintenance of hematopoietic stem cells (HSCs), which are regulated within a specialized bone marrow (BM) niche. When HSC sense external stimuli, their adhesion status may be critical for determining HSC cell fate. The cell surface molecule, integrin αvβ3, is activated through HSC adhesion to extracellular matrix and niche cells. Integrin β3 signaling maintains HSCs within the niche. Here, we showed the synergistic negative regulation of the pro-inflammatory cytokine interferon-γ (IFNγ) and β3 integrin signaling in murine HSC function by a novel definitive phenotyping of HSCs. Integrin αvβ3 suppressed HSC function in the presence of IFNγ and impaired integrin β3 signaling mitigated IFNγ-dependent negative action on HSCs. During IFNγ stimulation, integrin β3 signaling enhanced STAT1-mediated gene expression via serine phosphorylation. These findings show that integrin β3 signaling intensifies the suppressive effect of IFNγ on HSCs, which indicates that cell adhesion via integrin αvβ3 within the BM niche acts as a context-dependent signal modulator to regulate the HSC function under both steady-state and inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.