ArticleNeuropharmacology2017
Inhibition of the endocannabinoid-regulating enzyme monoacylglycerol lipase elicits a CB
Open access · greenAbstract read
In one paragraph
Article in Neuropharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Targeting the cholinergic and endocannabinoid systems as a therapeutic intervention for core and associated phenotypes in the autism model; a systematic review.Trends in psychiatry and psychotherapy · 2025Pooled it
- FAAH and MAGL inhibition: Evolving approaches to treating substance use disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Unraveling endocannabinoid signaling disruption in a preclinical model of neurodevelopmental disorders.The Journal of clinical investigation · 2025Article
- Effects of Repeated Treatment with the Monoacylglycerol Lipase Inhibitor MJN110 on Pain-Related Depression of Nesting and Cannabinoid 1 Receptor Function in Male and Female Mice.The Journal of pharmacology and experimental therapeutics · 2024Article
- Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer's Disease.International journal of molecular sciences · 2024Review
- Alpha/Beta-Hydrolase Domain-Containing 6: Signaling and Function in the Central Nervous System.Frontiers in pharmacology · 2021Review
- 2-Arachidonoylglycerol Modulation of Anxiety and Stress Adaptation: From Grass Roots to Novel Therapeutics.Biological psychiatry · 2020Review
- Molecular Mechanism and Cannabinoid Pharmacology.Handbook of experimental pharmacology · 2020Article
- ABHD6: Its Place in Endocannabinoid Signaling and Beyond.Trends in pharmacological sciences · 2019Review
- Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.Behavioural brain research · 2018Article
- A Prospective Evaluation of Drug Discrimination in Pharmacology.Current topics in behavioral neurosciencesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Robert A OwensDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Mohammed A MustafaDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Bogna M Ignatowska-JankowskaDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
M Imad DamajDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Patrick M BeardsleyDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Jenny L WileyRTI International, 3040 Cornwallis Road, Research Triangle Park, NC, 27709-2194, USA.
Micah J NiphakisThe Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Benjamin F CravattThe Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: aron.lichtman@vcuhealth.org.
Virginia Commonwealth University Medical Center · USScripps Research Institute · USRTI International · US
Funding
TRAINING IN THE PHARMACOLOGY OF ABUSED DRUGST32DA007027 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI William L. Dewey · 1985 to 2026
$14.7MVCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew Sean Halquist · 2014 to 2026
$13.8MCHEMOPROTEOMIC METHODS FOR SERINE HYDROLASE INHIBITOR DEVELOPMENTR01DA033760 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SCAMPAVIA, LOUIS DANIEL · 2012 to 2021
$5.1MTHC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9MEndocannabinoid modulation of pain-depressed behaviorR01DA030404 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI NEGUS, SIDNEY S, SIM-SELLEY, LAURA J · 2011 to 2020
$3.7MMonoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders (RO)R01DA032933 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, LICHTMAN, ARON H · 2012 to 2014
$1.5MEndocannabinoid DiscriminationR01DA026449 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI WILEY, JENNY L. · 2010 to 2014
$1.5MNIDA NIH HHS P30 DA033934NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA026449NIDA NIH HHS R01 DA030404NIDA NIH HHS R01 DA032933NIDA NIH HHS R01 DA033760NIDA NIH HHS T32 DA007027
Abstract
Substantial challenges exist for investigating the cannabinoid receptor type 1 (CB
Indexed as
AcetamidesAmidohydrolasesAnimalsBenzodioxolesCannabinoid Receptor ModulatorsCarbamatesCyclohexanolsCyclooxygenase 2Discrimination, PsychologicalDose-Response Relationship, DrugDronabinolEnzyme InhibitorsFatty Acid Amide HydrolasesMaleMice, Inbred C57BLMonoacylglycerol Lipases3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol4-(2-(4-chlorophenyl)ethyl)-1-piperidinecarboxylic acid 2-(methylamino)-2-oxoethyl esterABHD6 protein, mouseAcetamidesAmidohydrolasesBenzodioxolesCannabinoid Receptor ModulatorsCarbamatesCNR1 protein, mouseCyclohexanolsCyclooxygenase 2DronabinolEnzyme InhibitorsFatty Acid Amide HydrolasesJZL 184MJN110Monoacylglycerol LipasesPiperidinesPtgs2 protein, mousePyrazolesReceptor, Cannabinoid, CB1RimonabantSuccinimides2-Arachidonoylglycerol (2-AG)Alpha/beta-hydrolase domain 6 (ABHD6)Cannabinoid-1 (CB1) receptorCP55,940 (PubChem CID: 104895)Diazepam (PubChem CID: 3016)Discriminative stimulusDrug discriminationEndogenous cannabinoidsFatty acid amide hydrolase (FAAH)JZL184 (PubChem CID: 25021165)KT182 (PubChem CID: 53364491)MJN110 (PubChem CID: 71722059)Monoacylglycerol lipase (MAGL)N-arachidonoylethanolamine (anandamide, AEA)Nicotine (PubChem CID: 24278591)PF-3845 (PubChem CID: 25154867)Rimonabant (PubChem CID: 104850)SA-57 (PubChem CID: 44589122)Valdecoxib (PubChem CID: 119607)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.