Evidence map›Paper›PMID 28673314›Full record

ArticleArthritis research & therapy2017

Cardiovascular disease risk profiles in inflammatory joint disease entities.

Grunde Wibetoe, Eirik Ikdahl, Silvia Rollefstad, Inge C Olsen, Kjetil Bergsmark, Tore K Kvien, Anne Salberg, Dag Magnar Soldal, Gunnstein Bakland, Åse Lexberg and 4 more

Open access · goldAbstract read
In one paragraph

Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 1 country.

Grunde WibetoePreventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vinderen, N-0319, Oslo, Norway. g-wibeto@diakonsyk.no.
Eirik IkdahlPreventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vinderen, N-0319, Oslo, Norway.
Silvia RollefstadPreventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vinderen, N-0319, Oslo, Norway.
Inge C OlsenDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Kjetil BergsmarkDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Tore K KvienDepartment of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Anne SalbergLillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway.
Dag Magnar SoldalDepartment of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway.
Gunnstein BaklandDepartment of Rheumatology, University Hospital of Northern Norway, Tromsø, Norway.
Åse LexbergDepartment of Rheumatology, Vestre Viken Hospital, Drammen, Norway.
Bjørg-Tilde FevangDepartment of Rheumatology, Haukeland University Hospital, Bergen, Norway.
Hans Christian GulsethDepartment of Rheumatology, Betanien Hospital, Skien, Norway.
Glenn HaugebergDepartment of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway.
Anne Grete SembPreventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vinderen, N-0319, Oslo, Norway.
Diakonhjemmet Hospital · NOBetanien Hospital · NOHaukeland University Hospital · NOHospital of Southern Norway · NOMartina Hansens Hospital · NOUniversity Hospital of North Norway · NOVestre Viken Hospital Trust · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with inflammatory joint diseases (IJD) have increased risk of cardiovascular disease (CVD). Our aim was to compare CVD risk profiles in patients with IJD, including rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) and evaluate the future risk of CVD.

methodsThe prevalence and numbers of major CVD risk factors (CVD-RFs) (hypertension, elevated cholesterol, obesity, smoking, and diabetes mellitus) were estimated in patients with RA, axSpA and PsA. Relative and absolute risk of CVD according to Systematic Coronary Risk Evaluation (SCORE) was calculated.

resultsIn total, 3791 patients were included. CVD was present in 274 patients (7.2%). Of those without established CVD; hypertension and elevated cholesterol were the most frequent CVD-RFs, occurring in 49.8% and 32.8% of patients. Patients with PsA were more often hypertensive and obese. Overall, 73.6% of patients had a minimum of one CVD-RF, which increased from 53.2% among patients aged 30 to <45 years, to 86.2% of patients aged 60 to ≤80 years. Most patients (93.5%) had low/moderate estimated risk of CVD according to SCORE. According to relative risk estimations, 35.2% and 24.7% of patients had two or three times risk or higher, respectively, compared to individuals with no CVD-RFs.

conclusionsIn this nationwide Norwegian project, we have shown for the first time that prevalence and numbers of CVD-RFs were relatively comparable across the three major IJD entities. Furthermore, estimated absolute CVD risk was low, but the relative risk of CVD was markedly high in patients with IJD. Our findings indicate the need for CVD risk assessment in all patients with IJD.

Indexed as

AdultAgedArthritis, PsoriaticArthritis, RheumatoidCardiovascular DiseasesCohort StudiesFemaleHumansMaleMiddle AgedNorwayRisk FactorsSpondylitis, AnkylosingCardiovascularEpidemiologyRheumatoid arthritisSpondyloarthritisSpondyloarthropathies

Identifiers

PMID28673314
PMCPMC5496163
OpenAlexW2727124317

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.