ArticleCardiovascular ultrasound2017
Left ventricular outflow tract velocity time integral outperforms ejection fraction and Doppler-derived cardiac output for predicting outcomes in a select advanced heart failure cohort.
Article in Cardiovascular ultrasound, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Influence of maternal aerobic exercise during pregnancy on fetal cardiac function and outflow.American journal of obstetrics & gynecology MFM · 2020Trial
- Association of left ventricular outflow tract velocity-time integral with severity of pulmonary embolism in patients treated with catheter-directed therapies.Journal of thrombosis and thrombolysis · 2026Article
- Clinical risk score for cardiac death or heart failure hospitalization in moderate aortic stenosis.Echo research and practice · 2026Article
- Feasibility of measuring left ventricular outflow tract velocity time integral as a predictor for stroke volume in pregnant women in labor.The ultrasound journal · 2026Article
- Comparative Evaluation of Three Transthoracic Echocardiographic Techniques for Cardiac Output and Stroke Volume Assessment Across Hemodynamic States.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Effect of norepinephrine on ventricular systolic function during septic shock: the ENESySS study.Journal of anesthesia, analgesia and critical care · 2026Article
- Integrated ultrasound haemodynamic profiling (VTI-VExUS) for risk stratification in acute heart failure.European heart journal. Imaging methods and practice · 2026Article
- Cardiogenic Shock Systems of Care Best Practices. Part 1: Prehospital and Emergency Department Evaluation and Management.US cardiology · 2026Review
- Aged Zebrafish as a Spontaneous Model of Cardiac Valvular Disease.Aging cell · 2025Article
- Linking Heart Function to Prognosis: The Role of a Novel Echocardiographic Index and NT-proBNP in Acute Heart Failure.Medicina (Kaunas, Lithuania) · 2025Article
- Changes in Cardiac Function and Exercise Capacity Following Ferric Carboxymaltose Administration in HFrEF Patients with Iron Deficiency.Diagnostics (Basel, Switzerland) · 2025Article
- A combination of left ventricular outflow tract velocity time integral and lung ultrasound to predict mortality in ST elevation myocardial infarction.Internal and emergency medicine · 2024Article
- Contemporary clinical role of echocardiography in patients with advanced heart failure.Heart failure reviews · 2024Review
- Impact of guideline directed medical therapy on myocardial function in adults with congenital heart disease.International journal of cardiology · 2024Article
- New perspectives in the echocardiographic hemodynamics multiparametric assessment of patients with heart failure.Heart failure reviews · 2024Review
- Effects of short-term moderate intensity exercise on the serum metabolome in older adults: a pilot randomized controlled trial.Communications medicine · 2024Article
- Interrelationships between Peak Strain Dispersion, Myocardial Work Indices, Isovolumetric Relaxation and Systolic-Diastolic Coupling in Middle-Aged Healthy Subjects.Journal of clinical medicine · 2023Article
- Extracorporeal Membrane Oxygenation (VA-ECMO) in Management of Cardiogenic Shock.Journal of clinical medicine · 2023Review
- Exploring the predictive value of combined ultrasound parameters for spinal anesthesia-induced hypotension in cesarean section: a prospective observational study.BMC anesthesiology · 2023Observational
- Echocardiographic Evaluation of His Bundle Pacing in Patients with Prolonged PR Intervals.Cardiology and cardiovascular medicine · 2023Article
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Authors and funding
8 authors.
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Abstract
backgroundLeft ventricular outflow tract velocity time integral (LVOT VTI) is a measure of cardiac systolic function and cardiac output. Heart failure patients with low cardiac output are known to have poor cardiovascular outcomes. Thus, extremely low LVOT VTI may predict heart failure patients at highest risk for mortality.
methodsPatients with heart failure and extremely low LVOT VTI were identified from a single-center database. Baseline characteristics and heart failure related clinical outcomes (death, LVAD) were obtained at 12 months. Correlation between clinical endpoints and the following variables were analyzed: ejection fraction (EF), pulmonary artery systolic pressure (PASP), NYHA class, renal function, Doppler cardiac output (CO), and LVOT VTI.
resultsStudy cohort consisted of 100 patients. At the 12-month follow up period, 30 events (28 deaths, 2 LVADs) were identified. Occurrence of death and LVAD implantation was statistically associated with a lower LVOT VTI (p = 0.039) but not EF (p = 0.169) or CO (p = 0.217). In multivariate analysis, LVOT VTI (p = 0.003) remained statistically significant, other significant variables were age (p = 0.033) and PASP (p = 0.022). Survival analysis by LVOT VTI tertile demonstrated an unadjusted hazard ratio of 4.755 (CI 1.576-14.348, p = 0.006) for combined LVAD and mortality at one year.
conclusionsExtremely low LVOT VTI strongly predicts adverse outcomes and identifies patients who may benefit most from advanced heart failure therapies.
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