Evidence map›Paper›PMID 28673039›Full record

ReviewEndocrine reviews2017

A Reappraisal of Testosterone's Binding in Circulation: Physiological and Clinical Implications.

Anna L Goldman, Shalender Bhasin, Frederick C W Wu, Meenakshi Krishna, Alvin M Matsumoto, Ravi Jasuja

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrine reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 169 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 9 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 9 syntheses or guidelines pooled it, 392 citations in OpenAlex.

  1. Pooled it
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  6. Guideline
  7. Pooled it
  8. Global Consensus Position Statement on the Use of Testosterone Therapy for Women.The Journal of clinical endocrinology and metabolism · 2019
    Guideline
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  10. Trial
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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Anna L GoldmanResearch Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Frederick C W WuAndrology Research Unit, Centre for Endocrinology and Diabetes, University of Manchester, Manchester M13 9PT, United Kingdom.
Meenakshi KrishnaResearch Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Alvin M MatsumotoGeriatric Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108.
Ravi JasujaResearch Program in Men's Health: Aging and Metabolism, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Brigham and Women's Hospital · USUniversity of Manchester · GBUniversity of Washington · US

Funding

TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ravi Jasuja · 2008 to 2026
$23.9M
Mechanisms of Testosterone ActionR01AG037193 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI BHASIN, SHALENDER · 2010 to 2014
$2.2M
Novel Algorithm for Free Testosterone DeterminationR43AG045011 · NIA · FUNCTION PROMOTING THERAPIES, LLC · PI JASUJA, RAVI · 2014 to 2014
$225k
NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG037193NIA NIH HHS R43 AG045011
6 · The paper itself

Abstract

In the circulation, testosterone and other sex hormones are bound to binding proteins, which play an important role in regulating their transport, distribution, metabolism, and biological activity. According to the free hormone hypothesis, which has been debated extensively, only the unbound or free fraction is biologically active in target tissues. Consequently, accurate determination of the partitioning of testosterone between bound and free fractions is central to our understanding of how its delivery to the target tissues and biological activity are regulated and consequently to the diagnosis and treatment of androgen disorders in men and women. Here, we present a historical perspective on the evolution of our understanding of the binding of testosterone to circulating binding proteins. On the basis of an appraisal of the literature as well as experimental data, we show that the assumptions of stoichiometry, binding dynamics, and the affinity of the prevailing models of testosterone binding to sex hormone-binding globulin and human serum albumin are not supported by published experimental data and are most likely inaccurate. This review offers some guiding principles for the application of free testosterone measurements in the diagnosis and treatment of patients with androgen disorders. The growing number of testosterone prescriptions and widely recognized problems with the direct measurement as well as the computation of free testosterone concentrations render this critical review timely and clinically relevant.

Indexed as

HumansSerum Albumin, HumanSex Hormone-Binding GlobulinTestosteroneTranscortinSerum Albumin, HumanSex Hormone-Binding GlobulinTestosteroneTranscortin

Identifiers

PMID28673039
PMCPMC6287254
OpenAlexW2731671395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.