Evidence map›Paper›PMID 28672903›Full record

ArticleExperimental and therapeutic medicine2017

Efficacy of fulguration combined with imiquimod cream on condyloma acuminatum, and the effect on immune functions and serums levels of IL-2 and IL-10.

Quan Chen, Ridong Yang, Aili Gao, Daoqing Zhong, Huilan Zhu

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Quan ChenGuangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Ridong YangGuangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Aili GaoGuangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Daoqing ZhongGuangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Huilan ZhuGuangzhou Institute of Dermatology, Institute of Dermatology, Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China.
Guangzhou Medical University · CNGuangzhou Institute of Dermatology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of the present study was to investigate the clinical efficacy of high-frequency fulguration combined with 5% imiquimod cream for condyloma acuminatum (CA), and the effect on T cell immune function and serum levels of interleukin (IL)-2 and IL-10. We enrolled 112 patients with CA between January 2014 and January 2016. Patients were randomly divided into the control group (n=56) and observation group (n=56). The control group received high-frequency fulguration combined with intramuscular injection of Bacillus Calmette-Guérin polysaccharide nucleic acid, and the observation group received high-frequency fulguration combined with external application of 5% imiquimod cream. In both groups, the course of treatment lasted for 12 weeks, and the follow-up period was 6 months. Clinical efficacy was compared between the groups. The total effective rate in the observation group was higher than that in the control group (p<0.05), but no significant differences were identified in comparisons of effectiveness and recurrence rate between the two groups (p>0.05). After treatment, the levels of CD3

Indexed as

condyloma acuminatumfulgurationIL-10IL-2imiquimod creamT cell immune functions

Identifiers

PMID28672903
PMCPMC5488597
OpenAlexW2613135006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.