Calcineurin Antagonizes AMPK to Regulate Lipolysis in Caenorhabditis elegans.

Yanli Wang, Cangsang Xie, Zhiqing Diao, Bin Liang

Open access · goldAbstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 44% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

Molecular therapy. Nucleic acids · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yanli WangKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. 035wangyanli@163.com.

Cangsang XieKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. ywowen@126.com.

Zhiqing DiaoKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. datangchenjian@163.com.

Bin LiangKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. liangb@mail.kiz.ac.cn.

Kunming Institute of Zoology · CNAnhui University · CN

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026

$7.5M

NIH HHS P40 OD010440

6 · The paper itself

Abstract

Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase, and the target of immunosuppressive agent tacrolimus (TAC). The dysfunction of calcineurin, or clinical applications of tacrolimus, have been reported to be associated with dyslipidemia. The underlying mechanisms of calcineurin and tacrolimus in lipid metabolism are largely unknown. Here, we showed that mutations of

Indexed as

AMP-Activated Protein KinasesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCalcineurinCalcineurin InhibitorsGene Expression RegulationLipaseLipid MetabolismLipolysisMutationProtein Serine-Threonine KinasesTacrolimusAAK-2 protein, C elegansAMP-Activated Protein KinasesATGL-1 protein, C elegansCaenorhabditis elegans ProteinsCalcineurinCalcineurin InhibitorsLipaseProtein Serine-Threonine KinasesTacrolimusAMP-activated protein kinase (AMPK)calcineurinlipolysistacrolimustriglyceride lipase ATGL

Identifiers

PMID28672869

DOI10.3390/molecules22071062

PMCPMC6152104

OpenAlexW2706147183

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.