Evidence map›Paper›PMID 28672790›Full record

ReviewNutrients2017

Sugars, Sweet Taste Receptors, and Brain Responses.

Allen A Lee, Chung Owyang

Abstract readReview
In one paragraph

Review in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Low- or No-Energy Sweeteners and Body Weight Management: Dissecting a "Minor" Effect.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
  10. About Sugar Addiction.Brain and behavior · 2025
    Review
  11. Biomolecular Basis of Life.Metabolites · 2025
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Allen A Lee1500 East Medical Center Drive, Division of Gastroenterology, Department of Internal Medicine, Michigan Medicine, University of Michigan, Ann Arbor, MI 48109-5362, USA. allenlee@med.umcih.edu.
Chung Owyang3912 Taubman Center, SPC 5362, Ann Arbor, MI 48109-5362, USA. cowyang@med.umich.edu.

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
Mechanism of Glucose Sensing in Nodose ganglia in GI MotilityR01DK058913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiande Chen, JOHN W WILEY · 2001 to 2026
$6.4M
NIDDK NIH HHS P30 DK034933NIDDK NIH HHS R01 DK058913
6 · The paper itself

Abstract

Sweet taste receptors are composed of a heterodimer of taste 1 receptor member 2 (T1R2) and taste 1 receptor member 3 (T1R3). Accumulating evidence shows that sweet taste receptors are ubiquitous throughout the body, including in the gastrointestinal tract as well as the hypothalamus. These sweet taste receptors are heavily involved in nutrient sensing, monitoring changes in energy stores, and triggering metabolic and behavioral responses to maintain energy balance. Not surprisingly, these pathways are heavily regulated by external and internal factors. Dysfunction in one or more of these pathways may be important in the pathogenesis of common diseases, such as obesity and type 2 diabetes mellitus.

Indexed as

AnimalsBrainHumansReceptors, G-Protein-CoupledSugarsSweetening AgentsTasteTaste BudsReceptors, G-Protein-CoupledSugarsSweetening Agentsglucose sensinghypothalamusleptinnutrient sensingsweet taste receptors

Identifiers

PMID28672790
PMCPMC5537773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.