Evidence map›Paper›PMID 28672272›Full record

ArticleThe Journal of nutritional biochemistry2017

ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice.

Weicang Wang, Jun Yang, Yoshiki Nimiya, Kin Sing Stephen Lee, Katherine Sanidad, Weipeng Qi, Elvira Sukamtoh, Yeonhwa Park, Zhenhua Liu, Guodong Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  19. Chemoprevention of Colorectal Cancer by Dietary Compounds.International journal of molecular sciences · 2018
    Review
  20. Lipid metabolism and carcinogenesis, cancer development.American journal of cancer research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Weicang WangDepartment of Food Science, University of Massachusetts, Amherst, MA.
Jun YangDepartment of Entomology and Nematology, University of California, Davis, CA.
Yoshiki NimiyaDepartment of Food Science, University of Massachusetts, Amherst, MA; Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Tokyo, Japan.
Kin Sing Stephen LeeDepartment of Entomology and Nematology, University of California, Davis, CA.
Katherine SanidadMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA.
Weipeng QiDepartment of Food Science, University of Massachusetts, Amherst, MA.
Elvira SukamtohDepartment of Food Science, University of Massachusetts, Amherst, MA.
Yeonhwa ParkDepartment of Food Science, University of Massachusetts, Amherst, MA.
Zhenhua LiuMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA; Department of Nutrition, University of Massachusetts, Amherst, MA.
Guodong ZhangDepartment of Food Science, University of Massachusetts, Amherst, MA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA. Electronic address: guodongzhang@umass.edu.
University of Massachusetts Amherst · USUniversity of California, Davis · US

Funding

Identifying the receptors of environmentally sensitive epoxy-eicosanoids with AMSR00ES024806 · NIEHS · MICHIGAN STATE UNIVERSITY · PI LEE, KIN SING STEPHEN · 2017 to 2019
$727k
NIEHS NIH HHS R00 ES024806
6 · The paper itself

Abstract

Many studies have shown that dietary intake of ω-3 polyunsaturated fatty acids (PUFAs) reduces the risks of colorectal cancer; however, the underlying mechanisms are not well understood. Here we used a LC-MS/MS-based lipidomics to explore the role of eicosanoid signaling in the anti-colorectal cancer effects of ω-3 PUFAs. Our results showed that dietary feeding of ω-3 PUFAs-rich diets suppressed growth of MC38 colorectal tumor, and modulated profiles of fatty acids and eicosanoid metabolites in C57BL/6 mice. Notably, we found that dietary feeding of ω-3 PUFAs significantly increased levels of epoxydocosapentaenoic acids (EDPs, metabolites of ω-3 PUFA produced by cytochrome P450 enzymes) in plasma and tumor tissue of the treated mice. We further showed that systematic treatment with EDPs (dose=0.5 mg/kg per day) suppressed MC38 tumor growth in mice, with reduced expressions of pro-oncogenic genes such as C-myc, Axin2, and C-jun in tumor tissues. Together, these results support that formation of EDPs might contribute to the anti-colorectal cancer effects of ω-3 PUFAs.

Indexed as

AnimalsColorectal NeoplasmsCytochrome P-450 Enzyme SystemEicosanoidsFatty Acids, Omega-3Fatty Acids, UnsaturatedHumansMaleMice, Inbred C57BLTandem Mass SpectrometryXenograft Model Antitumor AssaysCytochrome P-450 Enzyme SystemEicosanoidsFatty Acids, Omega-3Fatty Acids, UnsaturatedColorectal cancerDocosahexaenoic acid (DHA)Epoxydocosapentaenoic acids (EDPs)Lipidomicsω-3 Polyunsaturated fatty acids (PUFAs)

Identifiers

PMID28672272
PMCPMC6278818
OpenAlexW2683929613

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.