Evidence map›Paper›PMID 28672156›Full record

ArticleStem cell research2017

Evidence for a retinal progenitor cell in the postnatal and adult mouse.

Xi Chen, Shaojun Wang, Haiwei Xu, Joao D Pereira, Konstantinos E Hatzistergos, Dieter Saur, Barbara Seidler, Joshua M Hare, Mark A Perrella, Zheng Qin Yin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Stimulation of C-KitFrontiers in pharmacology · 2022
    Article
  5. Review
  6. Multipotency of mouse trophoblast stem cells.Stem cell research & therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xi ChenSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shaojun WangSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Haiwei XuSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.
Joao D PereiraCardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Konstantinos E HatzistergosInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Dieter SaurMedicine II, Technische Universitaet Muenchen, Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Barbara SeidlerMedicine II, Technische Universitaet Muenchen, Munich, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.
Joshua M HareInterdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Mark A PerrellaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Zheng Qin YinSouthwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.
Xiaoli LiuDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: xlliu@rics.bwh.harvard.edu.

Funding

Mesenchymal Stromal Cell Conditioning by Carbon MonoxideP01HL108801 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2015
$13.8M
Rebuilding the Failing HeartP01HL092868 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANVERSA, PIERO · 2008 to 2013
$12.9M
Cardiomyocyte Differentiation Regulates Cardiac FunctionR01HL102897 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PERRELLA, MARK A · 2011 to 2014
$1.7M
NHLBI NIH HHS P01 HL092868NHLBI NIH HHS P01 HL108801NHLBI NIH HHS R01 HL102897
6 · The paper itself

Abstract

Progress in cell therapy for retinal disorders has been challenging. Recognized retinal progenitors are a heterogeneous population of cells that lack surface markers for the isolation of live cells for clinical implementation. In the present application, our objective was to use the stem cell factor receptor c-Kit (CD117), a surface marker, to isolate and evaluate a distinct progenitor cell population from retinas of postnatal and adult mice. Here we report that, by combining traditional methods with fate mapping, we have identified a c-Kit-positive (c-Kit

Indexed as

AgingAnimalsAnimals, NewbornCell LineageCell SeparationEpendymoglial CellsGreen Fluorescent ProteinsMiceMultipotent Stem CellsNeuronsProto-Oncogene Proteins c-kitRetinaStem CellsTamoxifenTime FactorsGreen Fluorescent ProteinsProto-Oncogene Proteins c-kitTamoxifenc-KitLineage tracingProgenitor cellsRetina

Identifiers

PMID28672156
PMCPMC6450801

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.