Evidence map›Paper›PMID 28672053›Full record

ArticleThe British journal of dermatology2017

A genome-wide association study suggests that MAPK14 is associated with diabetic foot ulcers.

W Meng, A Veluchamy, H L Hébert, A Campbell, H M Colhoun, C N A Palmer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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  12. Evolutionary Origins of Metabolic Reprogramming in Cancer.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

W MengDivision of Population Health Sciences, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD2 4BF, U.K.ORCID 0000-0001-5388-8494
A VeluchamyDivision of Population Health Sciences, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD2 4BF, U.K.
H L HébertDivision of Population Health Sciences, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD2 4BF, U.K.
A CampbellDivision of Population Health Sciences, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD2 4BF, U.K.
H M ColhounInstitute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, University of Edinburgh, Edinburgh, U.K.
C N A PalmerCentre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, DD2 4BF, U.K.
Ninewells Hospital · GBWestern General Hospital · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundDiabetic foot ulcers (DFUs) are a devastating complication of diabetes.

objectivesTo identify genetic contributors to the development of DFUs in the presence of peripheral neuropathy in a Scottish cohort with diabetes using a genome-wide association study.

methodsA genome-wide association approach was applied. A case was defined as a person with diabetes (type 1 or type 2) who had ever had a foot ulcer (current or previous) in at least one foot, as well as a positive monofilament test result (i.e. evidence of peripheral neuropathy) recorded in their longitudinal e-health records. A control was defined as an individual with diabetes (type 1 or type 2) who has never been recorded as having a foot ulcer in either foot but who had a positive monofilament test result recorded in either foot in their longitudinal e-health records.

resultsThere were 699 DFU cases and 2695 controls in the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) dataset. The single-nucleotide polymorphism rs80028505 (Chr6p21·31) in MAPK14 reached genome-wide significance with a lowest P-value of 2·45 × 10

conclusionsWe suggest that MAPK14 is associated with DFUs.

Indexed as

AgedCase-Control StudiesCohort StudiesDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic FootFemaleGenome-Wide Association StudyGenotypeHumansMaleMitogen-Activated Protein Kinase 14Polymorphism, Single NucleotideMitogen-Activated Protein Kinase 14

Identifiers

PMID28672053
PMCPMC5829525
OpenAlexW2732603385

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.