ArticlePloS one2017
Subcellular electrical stimulation of neurons enhances the myelination of axons by oligodendrocytes.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Direct and Gradual Electrical Testicular Shocks Stimulate Spermatogenesis and Activate Sperms in Infertile Men: A Randomized Controlled Trial.American journal of men's healthTrial
- Roll-to-Roll (R2R) High-Throughput Manufacturing of Foil-Based Microfluidic Chips for Neurite Outgrowth Studies.Micromachines · 2025Article
- Traumatic Spinal Cord Injury: Review of the Literature.Journal of clinical medicine · 2025Review
- Restore axonal conductance in a locally demyelinated axon with electromagnetic stimulation.Journal of neural engineering · 2025Article
- Biomaterials for neuroengineering: applications and challenges.Regenerative biomaterials · 2025Review
- Characterization of Contusive Spinal Cord Injury by Monitoring Motor-Evoked Potential.Biomedicines · 2024Article
- Article
- Article
- Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications.Lab on a chip · 2023Review
- The effects of electrical stimulation on glial cell behaviour.BMC biomedical engineering · 2022Review
- Brain physiome: A concept bridgingBioactive materials · 2022Review
- Neuroprotective Role of Hypothermia in Acute Spinal Cord Injury.Biomedicines · 2022Review
- Effects of central nervous system electrical stimulation on non-neuronal cells.Frontiers in neuroscience · 2022Review
- EngineeringAPL bioengineering · 2021Article
- Application of Optogenetics for Muscle Cells and Stem Cells.Advances in experimental medicine and biology · 2021Article
- Recent Developments in Prosthesis Sensors, Texture Recognition, and Sensory Stimulation for Upper Limb Prostheses.Annals of biomedical engineering · 2021Review
- Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review.Bioelectricity · 2020Review
- A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury.Neuromolecular medicine · 2020Review
- Biomedical applications of electrical stimulation.Cellular and molecular life sciences : CMLS · 2020Review
- Brain-on-a-chip: A history of development and future perspective.Biomicrofluidics · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myelin formation has been identified as a modulator of neural plasticity. New tools are required to investigate the mechanisms by which environmental inputs and neural activity regulate myelination patterns. In this study, we demonstrate a microfluidic compartmentalized culture system with integrated electrical stimulation capabilities that can induce neural activity by whole cell and focal stimulation. A set of electric field simulations was performed to confirm spatial restriction of the electrical input in the compartmentalized culture system. We further demonstrate that electrode localization is a key consideration for generating uniform the stimulation of neuron and oligodendrocytes within the compartments. Using three configurations of the electrodes we tested the effects of subcellular activation of neural activity on distal axon myelination with oligodendrocytes. We further investigated if oligodendrocytes have to be exposed to the electrical field to induce axon myelination. An isolated stimulation of cell bodies and proximal axons had the same effect as an isolated stimulation of distal axons co-cultured with oligodendrocytes, and the two modes had a non-different result than whole cell stimulation. Our platform enabled the demonstration that electrical stimulation enhances oligodendrocyte maturation and myelin formation independent of the input localization and oligodendrocyte exposure to the electrical field.
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Registered trials
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