ArticlePLoS biology2017
A multiscale cerebral neurochemical connectome of the rat brain.
Article in PLoS biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Neurochemical underpinning of hemodynamic response to neuropsychiatric drugs: A meta- and cluster analysis of preclinical studies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Pooled it
- Brain structural and functional connectivity converge prenatally but diverge after birth.PLoS biology · 2026Article
- The Cerebellar Connectome.Cerebellum (London, England) · 2026Article
- Behavioral Neurobiology of Alcohol Addiction: A Decade of Great Challenges, New Hopes, and Hypes.Current topics in behavioral neurosciences · 2025Review
- The exponential distance rule-based network model predicts topology and reveals functionally relevant properties of theNetwork neuroscience (Cambridge, Mass.) · 2025Article
- Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.Addiction biology · 2025Article
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- The brainstem connectome database.Scientific data · 2022Article
- Hypothalamic Neurochemical Changes in Long-Term Recovered Bilateral Subdiaphragmatic Vagotomized Rats.Frontiers in behavioral neuroscience · 2022Article
- Structural Attributes and Principles of the Neocortical Connectome in the Marmoset Monkey.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.Scientific reports · 2020Article
- Functional networks activated by controllable and uncontrollable stress in male and female rats.Neurobiology of stress · 2020Article
- Platform for micro-invasive membrane-free biochemical sampling of brain interstitial fluid.Science advances · 2020Article
- Anterior insula stimulation suppresses appetitive behavior while inducing forebrain activation in alcohol-preferring rats.Translational psychiatry · 2020Article
- Distinct structure-function relationships across cortical regions and connectivity scales in the rat brain.Scientific reports · 2020Article
- Mapping the community structure of the rat cerebral cortex with weighted stochastic block modeling.Brain structure & function · 2020Article
- Editorial: Neurobehavioural Mechanisms of Resilience and Vulnerability in Addictive Disorders.Frontiers in behavioral neuroscience · 2020Article
- Opposing roles for amygdala and vmPFC in the return of appetitive conditioned responses in humans.Translational psychiatry · 2019Article
- Distance-dependent consensus thresholds for generating group-representative structural brain networks.Network neuroscience (Cambridge, Mass.) · 2019Article
- Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs.Nature communications · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the rat neurochemical connectome is fundamental for exploring neuronal information processing. By using advanced data mining, supervised machine learning, and network analysis, this study integrates over 5 decades of neuroanatomical investigations into a multiscale, multilayer neurochemical connectome of the rat brain. This neurochemical connectivity database (ChemNetDB) is supported by comprehensive systematically-determined receptor distribution maps. The rat connectome has an onion-type structural organization and shares a number of structural features with mesoscale connectomes of mouse and macaque. Furthermore, we demonstrate that extremal values of graph theoretical measures (e.g., degree and betweenness) are associated with evolutionary-conserved deep brain structures such as amygdala, bed nucleus of the stria terminalis, dorsal raphe, and lateral hypothalamus, which regulate primitive, yet fundamental functions, such as circadian rhythms, reward, aggression, anxiety, and fear. The ChemNetDB is a freely available resource for systems analysis of motor, sensory, emotional, and cognitive information processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.