ArticlePLoS computational biology2017
Universal features of dendrites through centripetal branch ordering.
Article in PLoS computational biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- A modular framework for multi-scale tissue imaging and neuronal segmentation.Nature communications · 2024Article
- Pulmonary vasculature development in congenital diaphragmatic hernia: a novel automated quantitative imaging analysis.Pediatric surgery international · 2024Article
- Fractal Resonance: Can Fractal Geometry Be Used to Optimize the Connectivity of Neurons to Artificial Implants?Advances in neurobiology · 2024Article
- Topology recapitulates morphogenesis of neuronal dendrites.Cell reports · 2023Article
- Neuronal branching is increasingly asymmetric near synapses, potentially enabling plasticity while minimizing energy dissipation and conduction time.Journal of the Royal Society, Interface · 2023Article
- BDNF signaling in correlation-dependent structural plasticity in the developing visual system.PLoS biology · 2023Article
- How axon and dendrite branching are guided by time, energy, and spatial constraints.Scientific reports · 2022Article
- How neurons exploit fractal geometry to optimize their network connectivity.Scientific reports · 2021Article
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- Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient.Molecular brain · 2020Article
- Fractal analysis of concurrently prepared latex rubber casts of the bronchial and vascular systems of the human lung.Open biology · 2020Article
- Modelling brain-wide neuronal morphology via rooted Cayley trees.Scientific reports · 2018Article
- Direct induction of microtubule branching by microtubule nucleation factor SSNA1.Nature cell biology · 2018Article
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Authors and funding
4 authors.
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Abstract
Dendrites form predominantly binary trees that are exquisitely embedded in the networks of the brain. While neuronal computation is known to depend on the morphology of dendrites, their underlying topological blueprint remains unknown. Here, we used a centripetal branch ordering scheme originally developed to describe river networks-the Horton-Strahler order (SO)-to examine hierarchical relationships of branching statistics in reconstructed and model dendritic trees. We report on a number of universal topological relationships with SO that are true for all binary trees and distinguish those from SO-sorted metric measures that appear to be cell type-specific. The latter are therefore potential new candidates for categorising dendritic tree structures. Interestingly, we find a faithful correlation of branch diameters with centripetal branch orders, indicating a possible functional importance of SO for dendritic morphology and growth. Also, simulated local voltage responses to synaptic inputs are strongly correlated with SO. In summary, our study identifies important SO-dependent measures in dendritic morphology that are relevant for neural function while at the same time it describes other relationships that are universal for all dendrites.
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