ArticleThe American journal of sports medicine2017
In Vivo Tibial Cartilage Strains in Regions of Cartilage-to-Cartilage Contact and Cartilage-to-Meniscus Contact in Response to Walking.
Article in The American journal of sports medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute changes in knee cartilage and meniscus following long-distance running in habituate runners: a systematic review on studies using quantitative magnetic resonance imaging.Skeletal radiology · 2022Pooled it
- A deep learning-based approach for measuring patellar cartilage deformations from knee MR images.Journal of biomechanics · 2025Article
- Baseline-to-loaded changes in regional tibial cartilage thickness, T1ρ and T2: Utilization of an MRI compatible loading device.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Walking recovers cartilage compressive strain in vivo.Osteoarthritis and cartilage open · 2024Article
- Effect of functional knee loading on articular cartilage MRI T2 relaxation time and thickness in patients at risk for knee osteoarthritis.Osteoarthritis imaging · 2024Article
- Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing.Magnetic resonance in medicine · 2023Article
- The Interplay of Biomechanical and Biological Changes Following Meniscus Injury.Current rheumatology reports · 2023Review
- Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation.Journal of biomechanical engineering · 2022Article
- Effects of and Response to Mechanical Loading on the Knee.Sports medicine (Auckland, N.Z.) · 2022Review
- The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain.Orthopaedic journal of sports medicine · 2020Article
- Perlecan Knockdown Significantly Alters Extracellular Matrix Composition and Organization During Cartilage Development.Molecular & cellular proteomics : MCP · 2020Article
- Combined Injury to the ACL and Lateral Meniscus Alters the Geometry of Articular Cartilage and Meniscus Soon After Initial Trauma.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Meniscus-Derived Matrix Bioscaffolds: Effects of Concentration and Cross-Linking on Meniscus Cellular Responses and Tissue Repair.International journal of molecular sciences · 2019Article
- Mountain ultramarathon results in temporary meniscus extrusion in healthy athletes.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019Article
- Lateral Meniscal Graft Transplantation: Effect of Fixation Method on Joint Contact Mechanics During Simulated Gait.The American journal of sports medicine · 2019Article
- Computational Modeling of Developing Cartilage Using Experimentally Derived Geometries and Compressive Moduli.Journal of biomechanical engineering · 2019Article
- Activities of daily living influence tibial cartilage T1rho relaxation times.Journal of biomechanics · 2019Article
- Selective Enzymatic Digestion of Proteoglycans and Collagens Alters Cartilage T1rho and T2 Relaxation Times.Annals of biomedical engineering · 2019Article
- Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI.Arthritis research & therapy · 2018Article
- In Vivo Assessment of Exercise-Induced Glenohumeral Cartilage Strain.Orthopaedic journal of sports medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundThere are currently limited human in vivo data characterizing the role of the meniscus in load distribution within the tibiofemoral joint. Purpose/Hypothesis: The purpose was to compare the strains experienced in regions of articular cartilage covered by the meniscus to regions of cartilage not covered by the meniscus. It was hypothesized that in response to walking, tibial cartilage covered by the meniscus would experience lower strains than uncovered tibial cartilage. STUDY
designDescriptive laboratory study.
methodsMagnetic resonance imaging (MRI) of the knees of 8 healthy volunteers was performed before and after walking on a treadmill. Using MRI-generated 3-dimensional models of the tibia, cartilage, and menisci, cartilage thickness was measured in 4 different regions based on meniscal coverage and compartment: covered medial, uncovered medial, covered lateral, and uncovered lateral. Strain was defined as the normalized change in cartilage thickness before and after activity.
resultsWithin each compartment, covered cartilage before activity was significantly thinner than uncovered cartilage before activity ( P < .001). After 20 minutes of walking, all 4 regions experienced significant cartilage thickness decreases ( P < .01). The covered medial region experienced significantly less strain than the uncovered medial region ( P = .04). No difference in strain was detected between the covered and uncovered regions in the lateral compartment ( P = .40).
conclusionIn response to walking, cartilage that is covered by the meniscus experiences lower strains than uncovered cartilage in the medial compartment. These findings provide important baseline information on the relationship between in vivo tibial compressive strain responses and meniscal coverage, which is critical to understanding normal meniscal function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.