ArticleEnvironmental science & technology2017
An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.
Article in Environmental science & technology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Private, public, and bottled drinking water: Shared contaminant-mixture exposures and effects challenge.Environment international · 2025Pooled it
- Computational characterisation of ecological hazard and risk of environmental mixtures.EFSA journal. European Food Safety Authority · 2025Article
- Acute exposure to groundwater contaminants mixture of nitrate, atrazine and imidacloprid impacts growth kinetics of poultry cecal microbiomes and significantly decreases Caco-2 cell viability.bioRxiv : the preprint server for biology · 2025Article
- Emerging Contaminants in Source and Finished Drinking Waters Across Minnesota (U.S.) and Potential Health Implications.International journal of environmental research and public health · 2025Article
- Application of transcriptomics concentration-response modeling for prioritization of contaminants detected in tributaries of the North American Great Lakes.Environmental toxicology and chemistry · 2025Article
- Prioritizing chemicals of emerging concern in the Great Lakes Basin using covariance of chemical concentrations and diverse biological responses from a variety of species.Environmental toxicology and chemistry · 2025Article
- Article
- Article
- Mixed contaminant exposure in tapwater and the potential implications for human-health in disadvantaged communities in California.Water research · 2024Article
- In Vitro Screening for ToxCast Chemicals Binding to Thyroxine-Binding Globulin.Chemical research in toxicology · 2024Article
- Combining Nontargeted Analysis with Computer-Based Hazard Comparison Approaches to Support Prioritization of Unregulated Organic Contaminants in Biosolids.Environmental science & technology · 2024Article
- Integrating NHANES and toxicity forecaster data to compare pesticide exposure and bioactivity by farmwork history and US citizenship.Journal of exposure science & environmental epidemiology · 2024Article
- Multi-omic responses of fish exposed to complex chemical mixtures in the Shenandoah River watershed.The Science of the total environment · 2023Article
- Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Assessing utility of thyroid in vitro screening assays through comparisons to observed impacts in vivo.Regulatory toxicology and pharmacology : RTP · 2023Review
- Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- A framework for prioritizing contaminants in retrospective ecological assessments: Application in the Milwaukee Estuary (Milwaukee, WI).Integrated environmental assessment and management · 2023Article
- Exposures and potential health implications of contaminant mixtures in linked source water, finished drinking water, and tapwater from public-supply drinking water systems in Minneapolis/St. Paul area, USA.Environmental science : water research & technology · 2023Article
- Evaluation of Complex Mixture Toxicity in the Milwaukee Estuary (WI, USA) Using Whole-Mixture and Component-Based Evaluation Methods.Environmental toxicology and chemistry · 2023Article
- Juxtaposition of intensive agriculture, vulnerable aquifers, and mixed chemical/microbial exposures in private-well tapwater in northeast Iowa.The Science of the total environment · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Current environmental monitoring approaches focus primarily on chemical occurrence. However, based on concentration alone, it can be difficult to identify which compounds may be of toxicological concern and should be prioritized for further monitoring, in-depth testing, or management. This can be problematic because toxicological characterization is lacking for many emerging contaminants. New sources of high-throughput screening (HTS) data, such as the ToxCast database, which contains information for over 9000 compounds screened through up to 1100 bioassays, are now available. Integrated analysis of chemical occurrence data with HTS data offers new opportunities to prioritize chemicals, sites, or biological effects for further investigation based on concentrations detected in the environment linked to relative potencies in pathway-based bioassays. As a case study, chemical occurrence data from a 2012 study in the Great Lakes Basin along with the ToxCast effects database were used to calculate exposure-activity ratios (EARs) as a prioritization tool. Technical considerations of data processing and use of the ToxCast database are presented and discussed. EAR prioritization identified multiple sites, biological pathways, and chemicals that warrant further investigation. Prioritized bioactivities from the EAR analysis were linked to discrete adverse outcome pathways to identify potential adverse outcomes and biomarkers for use in subsequent monitoring efforts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.