ArticleBiomacromolecules2017
Photopolymerizable Zwitterionic Polymer Patterns Control Cell Adhesion and Guide Neural Growth.
Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Development of zwitterionic hydrogel thin film coatings of cochlear implant electrode arrays that reduce intracochlear inflammation and electrode impedance.Hearing research · 2026Article
- Photografted Zwitterionic Hydrogel Coating Durability for Reduced Foreign Body Response to Cochlear Implants.ACS applied bio materials · 2024Article
- Decreasing the physical gap in the neural-electrode interface and related concepts to improve cochlear implant performance.Frontiers in neuroscience · 2024Review
- Current advances in biomaterials for inner ear cell regeneration.Frontiers in neuroscience · 2023Review
- Cochlear implant material effects on inflammatory cell function and foreign body response.Hearing research · 2022Article
- Zwitterionic Polymer Coatings Enhance Gold Nanoparticle Stability and Uptake in Various Biological Environments.The AAPS journal · 2022Article
- Antifouling and Mechanical Properties of Photografted Zwitterionic Hydrogel Thin-Film Coatings Depend on the Cross-Link Density.ACS biomaterials science & engineering · 2021Article
- Photograftable Zwitterionic Coatings PreventACS applied bio materials · 2021Article
- Functionalizable Antifouling Coatings as Tunable Platforms for the Stress-Driven Manipulation of Living Cell Machinery.Biomolecules · 2020Article
- Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo.Advanced biosystems · 2020Article
- Bijel-templated implantable biomaterials for enhancing tissue integration and vascularization.Acta biomaterialia · 2019Article
- Antifouling Photograftable Zwitterionic Coatings on PDMS Substrates.Langmuir : the ACS journal of surfaces and colloids · 2019Article
- Tuning Surface and Topographical Features to Investigate Competitive Guidance of Spiral Ganglion Neurons.ACS applied materials & interfaces · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Developing materials that reduce or eliminate fibrosis encapsulation of neural prosthetic implants could significantly enhance implant fidelity by improving the tissue/electrode array interface. Here, we report on the photografting and patterning of two zwitterionic materials, sulfobetaine methacrylate (SBMA) and carboxybetaine methacrylate (CBMA), for controlling the adhesion and directionality of cells relevant to neural prosthetics. CBMA and SBMA polymers were photopolymerized and grafted on glass surfaces then characterized by X-ray photoelectron spectroscopy, water contact angle, and protein adsorption. Micropatterned surfaces were fabricated with alternating zwitterionic and uncoated bands. Fibroblasts, cells prevalent in fibrotic tissue, almost exclusively migrate and grow on uncoated bands with little to no cells present on zwitterionic bands, especially for CBMA-coated surfaces. Astrocytes and Schwann cells showed similarly low levels of cell adhesion and morphology changes when cultured on zwitterionic surfaces. Additionally, Schwann cells and inner ear spiral ganglion neuron neurites aligned well to zwitterionic patterns.
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Registered trials
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