ArticleNature neuroscience2017
Germline Chd8 haploinsufficiency alters brain development in mouse.
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In one paragraph
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 1 pooled it
13.5field-weighted citation impact, top 1% of its field
What it found
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Who cites it
162 citing papers in PubMed, 1 synthesis or guideline pooled it, 268 citations in OpenAlex.
- Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.American journal of human genetics · 2019Pooled it
- Homozygous CHD8 mutation intensifies ASD phenotypes and attenuates sex differences.Molecular psychiatry · 2026Article
- Zebrafish frk Gene Knockout Shows Social Impairments Relevant to Autism and Delays Brain Development by Increasing Cell Proliferation.Autism research : official journal of the International Society for Autism Research · 2026Article
- Autism and Neurodegeneration: Distinct Disorders or a Shared Biological Continuum?Brain sciences · 2026Review
- Myelin dysfunction in autism spectrum disorder: insights into core symptoms and mechanisms of brain development.Molecular psychiatry · 2026Review
- Molecular Acrobats: How CHD Remodelers Shape the Genetic Playground to License Cell Identity.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Brain and knee joint degeneration following anterior cruciate ligament injury in a mouse model of Alzheimer's disease.JBMR plus · 2026Article
- Male-Biased Social Deficits in Chd8Neuroscience bulletin · 2026Article
- Temporal and Cell-Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An Adnp frameshift variant disrupts Wnt signalling inducing chromatocytoskeletal defects and autism-related behaviour in male mice.EBioMedicine · 2026Article
- Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice.Nature communications · 2026Article
- A Novel Variant of theGenes · 2026Article
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency.Science advances · 2026Article
- Article
- Chromodomain helicase DNA-binding proteins and orofacial cleft.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Review
- Molecular interactions of Chd8 in mouse brain highlights a role in chromatin-associated RNA processing.bioRxiv : the preprint server for biology · 2025Article
- Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development.Cell genomics · 2025Article
- Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental Disorders.Journal of developmental biology · 2025Review
- Persistent cortical excitatory neuron dysregulation in adultResearch square · 2025Article
- Functional Neurogenomics to Dissect Disease Mechanisms Across Models.Annual review of genomics and human genetics · 2025Review
102 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 5 institutions in 2 countries.
Andrea L GompersDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Linda Su-FeherDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.ORCID http://orcid.org/0000-0002-0660-7925
Jacob EllegoodMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Nycole A CoppingDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
M Asrafuzzaman RiyadhDepartment of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis, Sacramento, California, USA.
Tyler W StradleighDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Michael C PrideDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Melanie D SchafflerDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
A Ayanna WadeDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.ORCID http://orcid.org/0000-0002-3318-2117
Rinaldo Catta-PretaDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.ORCID http://orcid.org/0000-0001-9833-1278
Iva ZdilarDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Shreya LouisDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.ORCID http://orcid.org/0000-0001-5752-6271
Gaurav KaushikDepartment of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis, Sacramento, California, USA.
Brandon J MannionLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.
Ingrid Plajzer-FrickLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.
Veena AfzalLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.
Axel ViselLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.ORCID http://orcid.org/0000-0002-4130-7784
Len A PennacchioLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.
Diane E DickelLawrence Berkeley National Laboratory, Functional Genomics Department, Berkeley, California, USA.
Jason P LerchMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
Jacqueline N CrawleyDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Konstantinos S ZarbalisDepartment of Pathology and Laboratory Medicine, Shriners Hospitals for Children, Institute for Pediatric Regenerative Medicine, University of California, Davis, Sacramento, California, USA.
Jill L SilvermanDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.
Alex S NordDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California, USA.ORCID http://orcid.org/0000-0003-4259-7514
University of California, Davis · USLawrence Berkeley National Laboratory · USShriners Hospitals for Children - Erie · USHospital for Sick Children · CAUniversity of Toronto · CA
Funding
Generation of an In Vivo Human Genome Transcriptional Enhancer DatasetR01HG003988 · NHGRI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Len Alexander Pennacchio · 2006 to 2026
$24.1MCenter for Mammalian Regulatory GenomicsU54HG006997 · NHGRI · LUDWIG INSTITUTE FOR CANCER RES LTD · PI REN, BING · 2012 to 2016
$14.3MUC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9MRodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI OZONOFF, SALLY · 2013 to 2019
$8.5MRegulation of Cardiac Development in Health and DiseaseUM1HL098166 · NHLBI · HARVARD MEDICAL SCHOOL · PI PENNACCHIO, LEN ALEXANDER, PU, WILLIAM TSWENCHING · 2015 to 2019
$4.4MFunctional Elucidation of the Sequence-Encoded Regulatory Activity of Enhancers in Vivo in the BrainR35GM119831 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Alexander Nord · 2016 to 2026
$3.9MGenome-Wide Resources for Transcriptional Enhancers Active in the Human HeartR24HL123879 · NHLBI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PENNACCHIO, LEN ALEXANDER, VISEL, AXEL · 2015 to 2019
$3.9MGenomic, Transgenic and Knockout Resources for Craniofacial Enhancer StudiesU01DE024427 · NIDCR · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI VISEL, AXEL · 2014 to 2018
$3.7MConvergent Synaptic Mechanisms in Neurodevelopmental DisordersR01NS085709 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CRAWLEY, JACQUELINE N, GALL, CHRISTINE M · 2013 to 2017
$2.8MTraining Program in Biomolecular TechnologyT32GM008799 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI LEACH, J. KENT · 2002 to 2016
$2.4MNHGRI NIH HHS R01 HG003988NHGRI NIH HHS U54 HG006997NHLBI NIH HHS R24 HL123879NHLBI NIH HHS UM1 HL098166NICHD NIH HHS U54 HD079125NIDCR NIH HHS U01 DE024427NIGMS NIH HHS R35 GM119831NIGMS NIH HHS T32 GM007377NIGMS NIH HHS T32 GM008799NINDS NIH HHS R01 NS085709
Abstract
The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8
Indexed as
AnimalsBrainCell Cycle ProteinsChromatinDNA-Binding ProteinsGene Expression Regulation, DevelopmentalGene Regulatory NetworksHaploinsufficiencyMice, TransgenicMutationPhenotypeTranscription FactorsCell Cycle ProteinsChromatinDNA-Binding Proteinsduplin protein, mouseTranscription Factors
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.