Evidence map›Paper›PMID 28671548›Full record

ArticleeLife2017

Motoneurons regulate the central pattern generator during drug-induced locomotor-like activity in the neonatal mouse.

Melanie Falgairolle, Joshua G Puhl, Avinash Pujala, Wenfang Liu, Michael J O'Donovan

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Recruitment of Motoneurons.Advances in neurobiology · 2022
    Article
  13. Article
  14. Optogenetic Activation of V1 Interneurons Reveals the Multimodality of Spinal Locomotor Networks in the Neonatal Mouse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  15. Review
  16. Article
  17. Recent Insights into the Rhythmogenic Core of the Locomotor CPG.International journal of molecular sciences · 2021
    Review
  18. Article
  19. Article
  20. Motoneuronal Spinal Circuits in Degenerative Motoneuron Disease.Frontiers in molecular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Melanie FalgairolleDevelopmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.ORCID 0000-0001-5243-4714
Joshua G PuhlDepartment of Entomology, University of Minnesota, Saint Paul, United States.
Avinash PujalaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Wenfang LiuDevelopmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.
Michael J O'DonovanDevelopmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, United States.ORCID 0000-0003-2487-7547
National Institutes of Health · USHoward Hughes Medical Institute · USUniversity of Minnesota · US

Funding

Mechanisms of Rhythmicity in the Spinal cordZIANS003022 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI O'DONOVAN, MICHAEL · 2009 to 2021
$18.7M
6 · The paper itself

Abstract

Motoneurons are traditionally viewed as the output of the spinal cord that do not influence locomotor rhythmogenesis. We assessed the role of motoneuron firing during ongoing locomotor-like activity in neonatal mice expressing archaerhopsin-3 (Arch), halorhodopsin (eNpHR), or channelrhodopsin-2 (ChR2) in Choline acetyltransferase neurons (ChAT

Indexed as

Action PotentialsAnimalsAnimals, NewbornCentral Pattern GeneratorsLightLocomotionMiceMotor NeuronsOptogeneticsarchaerhodopsinCPGlocomotionmotoneuronsmouseneuroscienceoptogeneticspinal cord

Identifiers

PMID28671548
PMCPMC5550280
OpenAlexW2725586270

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.