ArticleNature communications2017
Cobamide-mediated enzymatic reductive dehalogenation via long-range electron transfer.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Pooled it
- Isotopic Fractionation and Masking Effects during Biotransformation of Chlorinated Ethanes.Environmental science & technology · 2026Article
- Cofactor binding interactions with reductive dehalogenase shape cobamide utilization in organohalide-respiring bacteria.Communications biology · 2026Article
- Mechanism of FThe journal of physical chemistry. B · 2026Article
- Novel chemistry and structural perspectives in vitamin BChemical science · 2026Review
- Organohalide respiration by a Desulforhopalus-dominated community.The ISME journal · 2026Article
- Evidence of microbial reductive dehalogenation in deep-sea cold seeps and its implications for biogeochemical cycles.Microbiome · 2025Article
- Deciphering reductive dehalogenase specificity through targeted mutagenesis of chloroalkane reductases.Applied and environmental microbiology · 2025Article
- Update of the risk assessment of brominated phenols and their derivatives in food.EFSA journal. European Food Safety Authority · 2024Article
- Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances.Applied and environmental microbiology · 2024Review
- Understanding the sources, function, and irreplaceable role of cobamides in organohalide-respiring bacteria.Frontiers in microbiology · 2024Review
- Mechanisms and Opportunities for Rational In Silico Design of Enzymes to Degrade Per- and Polyfluoroalkyl Substances (PFAS).Journal of chemical information and modeling · 2023Review
- Structure of a membrane-bound menaquinol:organohalide oxidoreductase.Nature communications · 2023Article
- Accurate prediction by AlphaFold2 for ligand binding in a reductive dehalogenase and implications for PFAS (per- and polyfluoroalkyl substance) biodegradation.Scientific reports · 2023Article
- Chlorination of arenes via the degradation of toxic chlorophenols.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Spectroscopic and Computational Investigation of the Epoxyqueuosine Reductase QueG Reveals Intriguing Similarities with the Reductive Dehalogenase PceA.Biochemistry · 2022Article
- Recent advances and trends of trichloroethylene biodegradation: A critical review.Frontiers in microbiology · 2022Review
- Substrate-dependent competition and cooperation relationships between Geobacter and Dehalococcoides for their organohalide respiration.ISME communications · 2021Article
- Biocatalytic Reduction Reactions from a Chemist's Perspective.Angewandte Chemie (International ed. in English) · 2021Review
- Integrating single-cobalt-site and electric field of boron nitride in dechlorination electrocatalysts by bioinspired design.Nature communications · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capacity of metal-containing porphyrinoids to mediate reductive dehalogenation is implemented in cobamide-containing reductive dehalogenases (RDases), which serve as terminal reductases in organohalide-respiring microbes. RDases allow for the exploitation of halogenated compounds as electron acceptors. Their reaction mechanism is under debate. Here we report on substrate-enzyme interactions in a tetrachloroethene RDase (PceA) that also converts aryl halides. The shape of PceA's highly apolar active site directs binding of bromophenols at some distance from the cobalt and with the hydroxyl substituent towards the metal. A close cobalt-substrate interaction is not observed by electron paramagnetic resonance spectroscopy. Nonetheless, a halogen substituent para to the hydroxyl group is reductively eliminated and the path of the leaving halide is traced in the structure. Based on these findings, an enzymatic mechanism relying on a long-range electron transfer is concluded, which is without parallel in vitamin B
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.