ArticleLung India : official organ of Indian Chest Society
Predictors of mortality of severe sepsis among adult patients in the medical Intensive Care Unit.
Article in Lung India : official organ of Indian Chest Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prognostic factors of sepsis: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- The clinical significance of thrombocytopenia in sepsis and septic shock: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Optimised murine model of influenza-induced respiratory sepsis for studying acute kidney injury.Laboratory animal research · 2026Article
- Development and Validation of a Nomogram for Mortality Prediction in Septic Patients with Prolonged or Chronic Critical Illness.Diagnostics (Basel, Switzerland) · 2026Article
- Transforming Intracerebral Hemorrhage Care with Artificial Intelligence: Opportunities, Challenges, and Future Directions.Diagnostics (Basel, Switzerland) · 2026Review
- Device-measured capillary refill time identifies critically ill cases in the emergency department.Scientific reports · 2026Observational
- Mean arterial pressure at the initiation of continuous renal replacement therapy as a prognostic indicator in patients with acute kidney injury.Renal failure · 2025Observational
- Proenkephalin A 119-159 as a biomarker for predicting sepsis-associated acute kidney injury.International urology and nephrology · 2025Article
- Evaluating Compliance and Impact of the Sepsis Six Bundle in the Emergency Department: A Retrospective Cohort Study.Cureus · 2025Article
- Machine learning model to predict sepsis in ICU patients with intracerebral hemorrhage.Scientific reports · 2025Article
- Changes in immune cell signatures during early infection reflect decoupling of capillary perfusion and glycocalyx dimensions.Frontiers in immunology · 2025Observational
- Pediatric bacterial meningitis in southern China: analysis of 838 cases.Frontiers in cellular and infection microbiology · 2025Article
- Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.PloS one · 2025Article
- A multicentre prospective registry of one thousand sepsis patients admitted in Indian ICUs: (SEPSIS INDIA) study.Critical care (London, England) · 2024Article
- Point of care lactate for differentiating septic shock from hypovolemic shock in non-ICU settings: a prospective observational study.The Lancet regional health. Southeast Asia · 2024Article
- Hierarchical Capability in Distinguishing Severities of Sepsis via Serum Lactate: A Network Meta-Analysis.Biomedicines · 2024Review
- Hemodynamic Resuscitation Characteristics of Emergency Department Patients with Sepsis and Hypotension who are and are not Admitted to ICU; a Prospective Cross-sectional Study.Archives of academic emergency medicine · 2024Article
- Prediction of survival time after terminal extubation: the balance between critical care unit utilization and hospice medicine in the COVID-19 pandemic era.European journal of medical research · 2023Article
- Neutrophil CD64-a prognostic marker of sepsis in intensive care unit: a prospective cohort study.Frontiers in medicine · 2023Article
- Identifying and analyzing sepsis states: A retrospective study on patients with sepsis in ICUs.PLOS digital health · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is an important cause of mortality in the Intensive Care Units (ICUs) worldwide. Information regarding early predictive factors for mortality and morbidity is limited. AIMS AND
objectivesThe primary objective of the study was to estimate the mortality of severe sepsis among adult patients admitted into the medical ICU. The secondary objective was to identify the predictors associated with mortality. MATERIALS AND
methodsAdult patients admitted with severe sepsis in the medical ICU were studied. The primary outcome was the mortality among the study population. Baseline demographic, clinical, and laboratory data were recorded upon inclusion into the study. Risk factors associated with mortality were studied by univariate analysis. The variables having statistical significance were further included in multivariate analysis to identify the independent predictors of mortality.
resultsOut of eighty patients, 54 (67.5%) died. Univariate analysis showed that age >60 years, tachycardia, hypotension, elevated C-reactive protein (CRP) and lactate, thrombocytopenia, need of mechanical ventilation, and high Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment scores were variables associated with high mortality. The independent predictors of mortality identified by multivariate regression analysis were platelet count below 1 lakhs, serum levels of CRP >100, APACHE II score >25 on the day of admission to the ICU with severe sepsis, and the need for invasive mechanical ventilation.
conclusionsLow platelet count, elevated serum levels of CRP, APACHE score >25, and the need for invasive mechanical ventilation were found to be independent predictors of mortality of severe sepsis among adult patients with severe sepsis in the medical ICU.
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