Evidence map›Paper›PMID 28671116›Full record

ArticleJournal of Alzheimer's disease : JAD2017

Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI).

Manuel Montero-Odasso, Frederico Pieruccini-Faria, Robert Bartha, Sandra E Black, Elizabeth Finger, Morris Freedman, Barry Greenberg, David A Grimes, Robert A Hegele, Christopher Hudson and 13 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Link among apolipoprotein E E4, gait, and cognition in neurodegenerative diseases: ONDRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 1 country.

Manuel Montero-OdassoDepartment of Medicine, Division of Geriatric Medicine, Parkwood Hospital, University of Western Ontario, London, ON, Canada.
Frederico Pieruccini-FariaDepartment of Medicine, Division of Geriatric Medicine, Parkwood Hospital, University of Western Ontario, London, ON, Canada.
Robert BarthaDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
Sandra E BlackDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Elizabeth FingerDepartment of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Morris FreedmanDepartment of Medicine (Neurology), Baycrest Health Sciences and University of Toronto, Toronto, ON, Canada; Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, ON, Canada.
Barry GreenbergToronto Dementia Research Alliance, University Health Network, Toronto, ON, Canada.
David A GrimesDepartment of Medicine, The Ottawa Hospital, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Robert A HegeleDepartment of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Christopher HudsonSchool of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
Peter W KleinstiverSchulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Anthony E LangMorton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital and the Department of Medicine, University of Toronto, ON, Canada.
Mario MasellisDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Paula M McLaughlinSchulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Douglas P MunozCentre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Stephen StrotherDepartment of Medical Biophysics, Rotman Research Institute, Baycrest, University of Toronto, ON, Canada.
Richard H SwartzSunnybrook Health Sciences Centre, University of Toronto, Stroke Research Program, Toronto, ON, Canada.
Sean SymonsDepartment of Medical Imaging, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Maria Carmela TartagliaDepartment of Medicine and Division of Neurology, University of Toronto, Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, ON, Canada.
Lorne ZinmanDepartment of Medicine, Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Michael J StrongDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Robarts Research Institute, University of Western Ontario, London, ON, Canada.
ONDRI Investigators
William McIlroyCanadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Western University · CASunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of cognitive and motor impairments in Alzheimer's disease and other neurodegenerative diseases is thought to be related to damage in the common brain networks shared by cognitive and cortical motor control processes. These common brain networks play a pivotal role in selecting movements and postural synergies that meet an individual's needs. Pathology in this "highest level" of motor control produces abnormalities of gait and posture referred to as highest-level gait disorders. Impairments in cognition and mobility, including falls, are present in almost all neurodegenerative diseases, suggesting common mechanisms that still need to be unraveled.

objectiveTo identify motor-cognitive profiles across neurodegenerative diseases in a large cohort of patients.

methodsCohort study that includes up to 500 participants, followed every year for three years, across five neurodegenerative disease groups: Alzheimer's disease/mild cognitive impairment, frontotemporal degeneration, vascular cognitive impairment, amyotrophic lateral sclerosis, and Parkinson's disease. Gait and balance will be assessed using accelerometers and electronic walkways, evaluated at different levels of cognitive and sensory complexity, using the dual-task paradigm.

resultsComparison of cognitive and motor performances across neurodegenerative groups will allow the identification of motor-cognitive phenotypes through the standardized evaluation of gait and balance characteristics.

conclusionsAs part of the Ontario Neurodegenerative Research Initiative (ONDRI), the gait and balance platform aims to identify motor-cognitive profiles across neurodegenerative diseases. Gait assessment, particularly while dual-tasking, will help dissect the cognitive and motor contribution in mobility and cognitive decline, progression to dementia syndromes, and future adverse outcomes including falls and mortality.

Indexed as

Accidental FallsCohort StudiesCross-Sectional StudiesFemaleGait Disorders, NeurologicHumansMaleMotor ActivityNeurodegenerative DiseasesNeuropsychological TestsOntarioPostural BalanceSensation DisordersStatistics, NonparametricSurveys and QuestionnairesAlzheimer’s diseaseamyotrophic lateral sclerosisbalancedementiadual-taskingfrontotemporal dementiagaitneurodegenerationParkinson’s diseasevascular cognitive impairment

Identifiers

PMID28671116
PMCPMC5523841
OpenAlexW2733910087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.