Observational studyJournal of Alzheimer's disease : JAD2017
Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition.
Observational study in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05375513 (A Home-based Personalized Multidomain RCT from the Canadian Therapeutic Platform for Multidomain Interventions to Prevent Dementia), which is not on this map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Home-based Personalized Multidomain RCT from the Canadian Therapeutic Platform for Multidomain Interventions to Prevent Dementia (CAN-THUMBS UP)
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Multi-domain prognostic models used in middle-aged adults without known cognitive impairment for predicting subsequent dementia.The Cochrane database of systematic reviews · 2023Pooled it
- Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Alzheimer's disease genetic risk score and neuroimaging in the FINGER lifestyle trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Trial
- The Australian National University Alzheimer's Disease Risk Index (ANU-ADRI) score as a predictor for cognitive decline and potential surrogate outcome in the FINGER lifestyle randomized controlled trial.European journal of neurology · 2024Trial
- Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Trial
- 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial.Alzheimer's research & therapy · 2021Trial
- Metabolic and Neurocognitive Changes Following Lifestyle Modification: Examination of Biomarkers from the ENLIGHTEN Randomized Clinical Trial.Journal of Alzheimer's disease : JAD · 2020Trial
- Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).Alzheimer's research & therapy · 2019Trial
- Prediction of Episodic Memory With Multiomics Scores.Biological psychiatry global open science · 2026Article
- Neurophysiological correlates of modifiable dementia risk factors in cognitively unimpaired older adults.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Risk factors for Alzheimer's disease and cognitive function before middle age in a U.S. representative population-based study.Lancet regional health. Americas · 2025Article
- Comment on "Predicting cognitive function and dementia risk in patients with hypertension".Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Modifiable and Non-Modifiable Risk Factors for Dementia Among Non-Hispanic White and Black Populations Aged 50-64 in the United States, 2006-2016.Journal of geriatric psychiatry and neurology · 2025Article
- Enhancing dementia prediction: A 19-year validation of the CAIDE risk score with insulin resistance and APOE ε4 integration in a population-based cohort.The journal of prevention of Alzheimer's disease · 2025Article
- Exploring the Relationship Between CAIDE Dementia Risk and EEG Signal Activity in a Healthy Population.Brain sciences · 2024Article
- Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study.Age and ageing · 2024Article
- Association of modifiable risk factors with progression to dementia in relation to amyloid and tau pathology.Alzheimer's research & therapy · 2024Article
- Guideline for the cognitive assessment and follow-up in the Guangdong-Hong Kong-Macao Greater Bay Area (2024 edition).Aging medicine (Milton (N.S.W)) · 2024Article
- The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults.The British journal of psychiatry : the journal of mental science · 2024Article
- Predicting cognitive function and dementia risk in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 10 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCAIDE Dementia Risk Score is the first validated tool for estimating dementia risk based on a midlife risk profile.
objectivesThis observational study investigated longitudinal associations of CAIDE Dementia Risk Score with brain MRI, amyloid burden evaluated with PIB-PET, and detailed cognition measures.
methodsFINGER participants were at-risk elderly without dementia. CAIDE Risk Score was calculated using data from previous national surveys (mean age 52.4 years). In connection to baseline FINGER visit (on average 17.6 years later, mean age 70.1 years), 132 participants underwent MRI scans, and 48 underwent PIB-PET scans. All 1,260 participants were cognitively assessed (Neuropsychological Test Battery, NTB). Neuroimaging assessments included brain cortical thickness and volumes (Freesurfer 5.0.3), visually rated medial temporal atrophy (MTA), white matter lesions (WML), and amyloid accumulation.
resultsHigher CAIDE Dementia Risk Score was related to more pronounced deep WML (OR 1.22, 95% CI 1.05-1.43), lower total gray matter (β-coefficient -0.29, p = 0.001) and hippocampal volume (β-coefficient -0.28, p = 0.003), lower cortical thickness (β-coefficient -0.19, p = 0.042), and poorer cognition (β-coefficients -0.31 for total NTB score, -0.25 for executive functioning, -0.33 for processing speed, and -0.20 for memory, all p < 0.001). Higher CAIDE Dementia Risk Score including APOE genotype was additionally related to more pronounced MTA (OR 1.15, 95% CI 1.00-1.30). No associations were found with periventricular WML or amyloid accumulation.
conclusionsThe CAIDE Dementia Risk Score was related to indicators of cerebrovascular changes and neurodegeneration on MRI, and cognition. The lack of association with brain amyloid accumulation needs to be verified in studies with larger sample sizes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.