Evidence map›Paper›PMID 28670911›Full record

Trial reportAmerican journal of Alzheimer's disease and other dementias2017

Bioequivalence Study of Rivastigmine 6 mg Capsules (Single Dose) in Healthy Volunteers.

Dhiraj Abhyankar, Ashish Shedage, Milind Gole, Preeti Raut

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of Alzheimer's disease and other dementias, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dhiraj Abhyankar1 Cipla Ltd, R&D Centre, Mumbai, Maharashtra, India.
Ashish Shedage1 Cipla Ltd, R&D Centre, Mumbai, Maharashtra, India.
Milind Gole1 Cipla Ltd, R&D Centre, Mumbai, Maharashtra, India.
Preeti Raut1 Cipla Ltd, R&D Centre, Mumbai, Maharashtra, India.
Cipla (India) · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the bioequivalence of generic formulation of rivastigmine (test) and Exelon (reference).

methodsThis randomized, open-label, 2-period, single-dose, 2-treatment, 2-sequence, crossover study was conducted in 40 healthy men under fed condition. Participants were randomized to receive a single dose of Exelon or rivastigmine capsule.

resultsA total of 31 participants completed the study. Area under the concentration-time curve from time zero to time t (AUC

conclusionThe generic and reference formulations were bioequivalent, as the 90% CIs for C

Indexed as

AdultCapsulesCholinesterase InhibitorsCross-Over StudiesDrugs, GenericHealthy VolunteersHumansMaleRivastigmineTherapeutic EquivalencyYoung AdultCapsulesCholinesterase InhibitorsDrugs, GenericRivastigmineAlzheimerbioequivalenceLC-MS/MSpharmacokineticsrivastigmine

Identifiers

PMID28670911
PMCPMC10852838
OpenAlexW2728661460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.