ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2017
Impaired suppression of delay-period alpha and beta is associated with impaired working memory in schizophrenia.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Dose-Dependent Augmentation of Neuroplasticity-Based Auditory Learning in Schizophrenia: A Double-Blind, Placebo-Controlled, Randomized, Target Engagement Clinical Trial of the NMDA Glutamate Receptor Agonist d-serine.Biological psychiatry · 2023Trial
- Temporal Structure of Item Presentation Modulates Brain Oscillations in Verbal Working Memory.The European journal of neuroscience · 2026Article
- Frontal Theta Modulation in Sequential Working Memory: the Impact of Spatial Regularity and Scenario.Brain topography · 2025Article
- Seeing things in psychosis: Reduced theta power in early neural responses to ambiguous visual stimuli predicts perceptual distortions.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders.Schizophrenia bulletin · 2025Article
- Cost of maintaining attentional templates for multiple colors revealed by EEG decoding.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders.Frontiers in cellular neuroscience · 2024Review
- Cognitive Load Moderates the Effects of Total Sleep Deprivation on Working Memory: Evidence from Event-Related Potentials.Brain sciences · 2023Article
- Augmentation of learning in schizophrenia by D-serine is related to auditory and frontally-generated biomarkers: A randomized, double-blind, placebo-controlled study.Research square · 2023Article
- Attention in Schizophrenia.Current topics in behavioral neurosciences · 2023Article
- Dense attention network identifies EEG abnormalities during working memory performance of patients with schizophrenia.Frontiers in psychiatry · 2023Article
- The Role of Alpha Oscillations among the Main Neuropsychiatric Disorders in the Adult and Developing Human Brain: Evidence from the Last 10 Years of Research.Biomedicines · 2022Review
- Neural correlates of a load-dependent decline in visual working memory.Cerebral cortex communications · 2022Article
- Disrupted Modulation of Alpha and Low Beta Oscillations Mediates Temporal Sequence Memory Deficits in People With Schizophrenia.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Neural basis of the visual working memory deficit in schizophrenia: Merging evidence from fMRI and EEG.Schizophrenia research · 2021Article
- Reduced Dorsal Visual Oscillatory Activity During Working Memory Maintenance in the First-Episode Schizophrenia Spectrum.Frontiers in psychiatry · 2020Article
- A note on the identification of change detection task models to measure storage capacity and attention in visual working memory.Behavior research methods · 2019Article
- Mnemonic and attentional roles for states of attenuated alpha oscillations in perceptual working memory: a review.The European journal of neuroscience · 2018Review
- Electrophysiological correlates of encoding processes in a full-report visual working memory paradigm.Cognitive, affective & behavioral neuroscience · 2018Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundAlthough people with schizophrenia (PSZ) frequently exhibit reduced working memory capacity relative to healthy comparison subjects (HCS), the mechanisms that underlie this impairment are not yet known. The present study aimed to assess one putative mechanism: impaired suppression of alpha and beta frequency bands during the delay period of a visual working memory task.
methodsThe electroencephalogram (EEG) was recorded from 30 PSZ and 31 HCS while they completed a change detection task in which they were required to remember a briefly presented array of colored squares over an 1800-ms delay interval.
resultsOverall, we found that PSZ had significantly reduced alpha and beta-band suppression during the delay interval compared to HCS, and that these significant differences emerged early (100-200 ms after the onset of the memory array). Furthermore, the magnitude of suppression was significantly associated with task performance across both groups. Finally, the magnitude of suppression in alpha and beta frequency bands was significantly associated with a range of cognitive measures among HCS, but not PSZ.
conclusionsThese results implicate impaired alpha/beta suppression during the consolidation period of working memory tasks as a promising neural mechanism that constrains capacity in PSZ.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.