Evidence map›Paper›PMID 28670618›Full record

ArticleeNeuro

Minute Impurities Contribute Significantly to Olfactory Receptor Ligand Studies: Tales from Testing the Vibration Theory.

M Paoli, D Münch, A Haase, E Skoulakis, L Turin, C G Galizia

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. In Vivo Two-Photon Imaging of the Olfactory System in Insects.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  7. Article
  8. Article
  9. Transport features predict if a molecule is odorous.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Sensory Perception of Non-Deuterated and Deuterated Organic Compounds.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  11. Olfactory coding in honeybees.Cell and tissue research · 2021
    Review
  12. Article
  13. Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

M PaoliNeurobiology, University of Konstanz, Konstanz, 78457, Germany.ORCID 0000-0001-5672-1403
D MünchNeurobiology, University of Konstanz, Konstanz, 78457, Germany.ORCID 0000-0003-3271-1651
A HaaseDepartment of Physics and Center for Mind/Brain Sciences, University of Trento, Povo, TN 38123, Italy.ORCID 0000-0002-8324-0047
E SkoulakisDivision of Neuroscience, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece.ORCID 0000-0001-5113-6192
L TurinDivision of Neuroscience, Biomedical Sciences Research Centre Alexander Fleming, Vari 16672, Greece.ORCID 0000-0003-0878-6696
C G GaliziaNeurobiology, University of Konstanz, Konstanz, 78457, Germany.ORCID 0000-0001-8292-6031
University of Konstanz · DEAlexander Fleming Biomedical Sciences Research Center · GRUniversity of Trento · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have attempted to test the vibrational hypothesis of odorant receptor activation in behavioral and physiological studies using deuterated compounds as odorants. The results have been mixed. Here, we attempted to test how deuterated compounds activate odorant receptors using calcium imaging of the fruit fly antennal lobe. We found specific activation of one area of the antennal lobe corresponding to inputs from a specific receptor. However, upon more detailed analysis, we discovered that an impurity of 0.0006% ethyl acetate in a chemical sample of benzaldehyde-d

Indexed as

VibrationAnimalsAnimals, Genetically ModifiedArthropod AntennaeCalciumDrosophila melanogasterDrosophila ProteinsFemaleGreen Fluorescent ProteinsOdorantsOlfactory PathwaysOlfactory Receptor NeuronsReceptors, OdorantSmellTranscription FactorsCalciumDrosophila ProteinsGAL4 protein, DrosophilaGreen Fluorescent ProteinsOr42b protein, DrosophilaReceptors, OdorantTranscription Factorsdeuterationolfactory receptorsvibration theory

Identifiers

PMID28670618
PMCPMC5490255
OpenAlexW2621671601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.