Evidence map›Paper›PMID 28670580›Full record

ArticleFrontiers in veterinary science2017

Whole Genome Sequencing of a Canadian Bovine Gammaherpesvirus 4 Strain and the Possible Link between the Viral Infection and Respiratory and Reproductive Clinical Manifestations in Dairy Cattle.

Carl A Gagnon, Carolina Kist Traesel, Nedzad Music, Jérôme Laroche, Nicolas Tison, Jean-Philippe Auger, Sanela Music, Chantale Provost, Christian Bellehumeur, Levon Abrahamyan and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Carl A GagnonSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Carolina Kist TraeselSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Nedzad MusicSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Jérôme LarocheInstitut de biologie intégrative et des systèmes (IBIS), Université Laval, Québec, QC, Canada.
Nicolas TisonDépartement des Sciences cliniques, FMV, Université de Montréal, St-Hyacinthe, QC, Canada.
Jean-Philippe AugerSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Sanela MusicSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Chantale ProvostSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Christian BellehumeurSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Levon AbrahamyanSwine and Poultry Infectious Diseases Research Center (CRIPA) and Groupe de recherche sur les maladies infectieuses en production animale (GREMIP), Faculté de médecine vétérinaire (FMV), Université de Montréal, St-Hyacinthe, QC, Canada.
Susy CarmanAnimal Health Laboratory, Laboratory Services Division, University of Guelph, Guelph, ON, Canada.
Luc DesCôteauxDépartement des Sciences cliniques, FMV, Université de Montréal, St-Hyacinthe, QC, Canada.
Steve J CharetteInstitut de biologie intégrative et des systèmes (IBIS), Université Laval, Québec, QC, Canada.
Université de Montréal · CAInstitut Universitaire de Cardiologie et de Pneumologie de Québec · CAUniversité Laval · CAUniversity of Guelph · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine gammaherpesvirus 4 (BoHV-4) is a herpesvirus widespread in cattle populations, and with no clear disease association. Its genome contains a long unique coding region (LUR) flanked by polyrepetitive DNA and 79 open reading frames (ORFs), with unique 17 ORFs, named Bo1 to Bo17. In 2009, a BoHV-4 strain was isolated (FMV09-1180503: BoHV-4-FMV) from cattle with respiratory disease from Quebec, Canada, and its LUR was sequenced. Despite the overall high similarity, BoHV-4-FMV had the most divergent LUR sequence compared to the two known BoHV-4 reference strain genomes; most of the divergences were in the Bo genes and in the repeat regions. Our phylogenetic analysis based on DNA polymerase and thymidine kinase genes revealed that virus isolate was BoHV-4 gammaherpesvirus and clustered it together with European BoHV-4 strains. Because BoHV-4-FMV was isolated from animals presenting respiratory signs, we have updated the BoHV-4 Canadian cattle seroprevalence data and tried to find out whether there is a link between clinical manifestation and BoHV-4 seropositivity. An indirect immunofluorescence assay (IFA) was performed with nearly 200 randomized sera of dairy cattle from two Canadian provinces, Quebec (

Indexed as

bovine gammaherpesvirus 4cattle infectious diseaseslong unique coding regionphylogenetic analysisseroprevalence

Identifiers

PMID28670580
PMCPMC5472674
OpenAlexW2626933500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.