ReviewFrontiers in pediatrics2017
Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis, and Treatment with Omics.
Review in Frontiers in pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Cerebrospinal Procalcitonin for Diagnosing Meningitis in Infants Less Than 90 Days: A Systematic Review and Meta-analysis.Indian pediatrics · 2025Pooled it
- Pooled it
- Clinical characteristics and outcomes of early-onset neonatal bacterial meningitis: a 20-year retrospective comparison of preterm and full-term infants.BMC pediatrics · 2026Article
- Epidemiology and Outcomes of Culture-proven Neonatal Meningitis in Australian Tertiary Hospitals: A Multicenter Retrospective Cohort Study.The Pediatric infectious disease journal · 2026Article
- Development and internal validation of a prognostic nomogram for poor outcomes in neonatal bacterial meningitis.Translational pediatrics · 2026Article
- Corticosteroids as adjunctive therapy in acute meningitis: a narrative review.Annals of medicine and surgery (2012) · 2026Review
- Article
- Neonatal-Onset Chronic Granulomatous Disease Presenting With Recurrent Culture-Negative Meningitis: A Case Report and Diagnostic Considerations.Case reports in immunology · 2026Article
- Determinants of Prolonged Antibiotic Administration in Culture-Negative Evaluations of Early-Onset Neonatal Meningitis: A Retrospective Cohort Study.Antibiotics (Basel, Switzerland) · 2025Article
- Consequences of host-microbiome interactions in preterm infants.Infection and immunity · 2025Review
- Ten-year review of hospital-acquired neonatal meningitis in a tertiary-level NICU: the important role of acinetobacter species.BMC infectious diseases · 2025Article
- Diagnostic Utility of Procalcitonin and Lactate Determination in Cerebrospinal Fluid for the Diagnosis of Neonatal Meningitis.Journal of clinical medicine · 2025Article
- Construction and Validation of a Nomogram Model for Predicting the Risk of Neonatal Sepsis Complicated by Purulent Meningitis.Journal of inflammation research · 2025Article
- Epidemiology and outcomes of bacterial meningitis in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Bacterial Meningitis in Infants Under 90 Days of Age: A Retrospective Single-Center Study.Children (Basel, Switzerland) · 2024Article
- Unveiling the Novel Impact of Vitamin D Injections at Birth on the Prognosis of Newborns: A Double-blind Study.Oman medical journal · 2024Article
- Case report: an infant with late-onset meningitis caused by Escherichia coli.GMS hygiene and infection control · 2024Article
- Burden and bacterial etiology of neonatal meningitis at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia.PloS one · 2024Article
- Lumbar Puncture and Meningitis in Infants with Proven Early- or Late-Onset Sepsis: An Italian Prospective Multicenter Observational Study.Microorganisms · 2023Article
- Late-Onset Sepsis Mortality among Preterm Infants: Beyond Time to First Antibiotics.Microorganisms · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal meningitis is a devastating condition. Prognosis has not improved in decades, despite the advent of improved antimicrobial therapy and heightened index of suspicion among clinicians caring for affected infants. One in ten infants die from meningitis, and up to half of survivors develop significant lifelong complications, including seizures, impaired hearing and vision, and delayed or arrested development of such basic skills as talking and walking. At present, it is not possible to predict which infants will suffer poor outcomes. Early treatment is critical to promote more favorable outcomes, though diagnosis of meningitis in infants is technically challenging, time-intensive, and invasive. Profound neuronal injury has long been described in the setting of neonatal meningitis, as has elevated levels of many pro- and anti-inflammatory cytokines. Mechanisms of the host immune response that drive clearance of the offending organism and underlie brain injury due to meningitis are not well understood, however. In this review, we will discuss challenges in diagnosis, prognosis, and treatment of neonatal meningitis. We will highlight transcriptomic, proteomic, and metabolomic data that contribute to suggested mechanisms of inflammation and brain injury in this setting with a view toward fruitful areas for future investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.