ArticleKorean journal of orthodontics2017
Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study.
Article in Korean journal of orthodontics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Botulinum toxin type A injection into the masticatory muscles and its effects on mandibular bone resorption and density. A systematic review.Clinical oral investigations · 2024Pooled it
- Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects?Clinical oral investigations · 2019Pooled it
- Longitudinal Computed Tomography Indicates No Negative Impact of OnabotulinumtoxinA on Mandibular Bone Density in a 12-Month, Double-Blind, Randomized, Repeat Treatment, Placebo-Controlled Study in Healthy Adults With Masseter Muscle Prominence.Aesthetic surgery journal · 2025Trial
- Comparing botulinum toxin and biofeedback therapies for awake bruxism: a randomized clinical trial.BMC oral health · 2025Trial
- Trial
- Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial.Toxins · 2020Trial
- Review
- Do mandibular functional units exhibit inherent asymmetry in adults with a normal degree of chin deviation? A cone-beam computed tomography study.Scientific reports · 2026Article
- Anatomical Mapping of the Masseter for Safe Botulinum Toxin Injection: A Cadaveric Study.BioMed research international · 2026Article
- Is Mandibular Cortical Bone and Trabecular Microarchitecture Altered by Masseter Botox Treatment? A Quantitative Perspective.Diagnostics (Basel, Switzerland) · 2025Article
- The effects of masseter muscle morphology on three-dimensional occlusion and temporomandibular joint in adult patients with skeletal class II malocclusion: a CBCT study.BMC oral health · 2025Article
- Factors Influencing the Effectiveness of Botulinum Toxin Therapy in Bruxism Management.Toxins · 2025Article
- Ultrasound-Guided Botulinum Toxin-A Injections into the Masseter Muscle for Both Medical and Aesthetic Purposes.Toxins · 2024Review
- Evaluation of mandibular trabecular and cortical bone by fractal analysis and radiomorphometric indices in bruxist and non-bruxist patients.BMC oral health · 2023Article
- Tridimensional assessment of the mandibular angle in patients with different skeletal patterns by cone-beam computed tomography scans: a retrospective study.BMC oral health · 2023Article
- Botulinum Toxin Type A for the Treatment of Masseter Muscle Prominence in Asian Populations.Aesthetic surgery journal. Open forum · 2023Review
- Automatic Masseter Muscle Accurate Segmentation from CBCT Using Deep Learning-Based Model.Journal of clinical medicine · 2022Article
- Botulinum Toxin Therapy for Oromandibular Dystonia and Other Movement Disorders in the Stomatognathic System.Toxins · 2022Review
- Validity and reliability of masseter muscles segmentation from the transverse sections of Cone-Beam CT scans compared with MRI scans.International journal of computer assisted radiology and surgery · 2022Article
- Botulinum toxin and occlusal splints for the management of sleep bruxism in individuals with implant overdentures: A randomized controlled trial.The Saudi dental journal · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate soft- and hard-tissue changes in the mandibular angle area after the administration of botulinum toxin type A (BoNT-A) injection to patients with masseteric hypertrophy by using three-dimensional cone-beam computed tomography (3D-CBCT).
methodsTwenty volunteers were randomly divided into two groups of 10 patients. Patients in group I received a single BoNT-A injection in both masseter muscles, while those in group II received two BoNT-A injections in each masseter muscle, with the second injection being administered 4 months after the first one. In both groups, 3D-CBCT was performed before the first injection and 6 months after the first injection.
resultsMasseter muscle thicknesses and cross-sectional areas were significantly reduced in both groups, but the reductions were significantly more substantial in group II than in group I. The intergonial width of the mandibular angle area did not change significantly in either group. However, the bone volume of the mandibular gonial angle area was more significantly reduced in group II than in group I.
conclusionsThe repeated administration of BoNT-A injections may induce bone volume changes in the mandibular angle area.
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