Evidence map›Paper›PMID 28670464›Full record

ArticleFuture science OA2017

Diagnostic value of blood thiamine metabolites in Alzheimer's disease examined by

Zhichun Chen, Xiaoli Pan, Guoqiang Fei, Shumei Pan, Weiqi Bao, Shuhua Ren, Yihui Guan, Chunjiu Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future science OA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhichun ChenDepartment of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Institute of Brain Science & Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Xiaoli PanDepartment of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Institute of Brain Science & Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Guoqiang FeiDepartment of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Institute of Brain Science & Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Shumei PanDepartment of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Institute of Brain Science & Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Weiqi BaoPET center, Huashan Hospital, Fudan University, Shanghai 200443, China.
Shuhua RenPET center, Huashan Hospital, Fudan University, Shanghai 200443, China.
Yihui GuanPET center, Huashan Hospital, Fudan University, Shanghai 200443, China.
Chunjiu ZhongDepartment of Neurology, Zhongshan Hospital & Shanghai Medical College, State Key Laboratory of Medical Neurobiology, Institute of Brain Science & Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimWe evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with

methodsThirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received

resultsThiamine diphosphate (TDP) had 66.7% sensitivity and 80.0% specificity for AD diagnosis, while the γ-value representing the best combination of thiamine metabolites and age had 24.2% sensitivity and 100.0% specificity according to the cut-off value of our previous study.

conclusionBlood TDP but not γ-value exhibited results significant for AD diagnosis.

Indexed as

Alzheimer’s diseaseblood biomarkerdiagnosisPiB negativePiB positivepositron emission tomography with 11C-Pittsburgh compound Bthiaminethiamine diphosphatethiamine metabolitesγ-value

Identifiers

PMID28670464
PMCPMC5481811

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.