ArticleRSC advances2017
Short-term hypoxic preconditioning promotes prevascularization in 3D bioprinted bone constructs with stromal vascular fraction derived cells.
Article in RSC advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Biofabrication for complex tissue regeneration: a scoping review of translational gaps in craniomaxillofacial reconstruction.Frontiers in oral health · 2026Review
- Optimizing methods for regenerative endodontics.Regenerative medicine · 2025Review
- Innovative Approaches in Bone Tissue Engineering: Strategies for Cancer Treatment and Recovery.International journal of molecular sciences · 2025Review
- Stem Cells Within Three-Dimensional-Printed Scaffolds Facilitate Airway Mucosa and Bone Regeneration and Reconstruction of Maxillary Defects in Rabbits.Medicina (Kaunas, Lithuania) · 2024Article
- The impact of the physicochemical properties of calcium phosphate ceramics on biocompatibility and osteogenic differentiation of mesenchymal stem cells.BMC research notes · 2024Article
- Intelligent Vascularized 3D/4D/5D/6D-Printed Tissue Scaffolds.Nano-micro letters · 2023Review
- In Vitro and In Vivo Biological Assessments of 3D-Bioprinted Scaffolds for Dental Applications.International journal of molecular sciences · 2023Review
- The Role of HIF-1α in Bone Regeneration: A New Direction and Challenge in Bone Tissue Engineering.International journal of molecular sciences · 2023Review
- Advanced Hydrogel systems for mandibular reconstruction.Bioactive materials · 2023Review
- Up-to-date progress in bioprinting of bone tissue.International journal of bioprinting · 2023Review
- Biomaterials-based additive manufacturing for customized bioengineering in management of otolaryngology: a comprehensive review.Frontiers in bioengineering and biotechnology · 2023Review
- Systematic review on the application of 3D-bioprinting technology in orthoregeneration: current achievements and open challenges.Journal of experimental orthopaedics · 2022Review
- Current Advances of Three-Dimensional Bioprinting Application in Dentistry: A Scoping Review.Materials (Basel, Switzerland) · 2022Article
- Additive Manufactured Polymers in Dentistry, Current State-of-the-Art and Future Perspectives-A Review.Polymers · 2022Review
- 3D bioprinting in tissue engineering and regenerative medicine.Cell and tissue banking · 2022Review
- State of the field: cellular and exosomal therapeutic approaches in vascular regeneration.American journal of physiology. Heart and circulatory physiology · 2022Review
- Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation.Bioactive materials · 2022Article
- Customized Design 3D Printed PLGA/Calcium Sulfate Scaffold Enhances Mechanical and Biological Properties for Bone Regeneration.Frontiers in bioengineering and biotechnology · 2022Article
- Materials for Dentoalveolar Bioprinting: Current State of the Art.Biomedicines · 2021Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reconstruction of complex, craniofacial bone defects often requires autogenous vascularized bone grafts, and still remains a challenge today. In order to address this issue, we isolated the stromal vascular fraction (SVF) from adipose tissues and maintained the phenotypes and the growth of endothelial lineage cells within SVF derived cells (SVFC) by incorporating an endothelial cell medium. We 3D bioprinted SVFC within our hydrogel bioinks and conditioned the constructs in either normoxia or hypoxia. We found that short-term hypoxic conditioning promoted vascularization-related gene expression, whereas long-term hypoxia impaired cell viability and vascularization. 3D bioprinted bone constructs composed of polycaprolactone/hydroxyapatite (PCL/HAp) and SVFC-laden hydrogel bioinks were then implanted into athymic mice, after conditioning in normoxic or short-term hypoxic environments, in order to determine the
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.