ArticleAdvanced functional materials2016
Design of Multistimuli Responsive Hydrogels Using Integrated Modeling and Genetically Engineered Silk-Elastin-Like Proteins.
Article in Advanced functional materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Dynamic Silk Fibroin Hydrogels for Programmable Bioactuation and Smart Shape Deformation: Mechanisms, Performance Evaluation, and Biomedical Applications.Gels (Basel, Switzerland) · 2026Review
- Ultrafast crosslinking, strongly adhesiveBioactive materials · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Genetically Engineered Light-Responsive In Situ Hydrogels for Immunomodulation and Multimodal Therapy in Metastatic Triple-Negative Breast Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Genetic and bioactive functionalization of bioinks for 3D bioprinting.Bioprocess and biosystems engineering · 2025Review
- Molecular Engineering of Recombinant Protein Hydrogels: Programmable Design and Biomedical Applications.Gels (Basel, Switzerland) · 2025Review
- Electrochemical-Genetic Programming of Protein-Based Magnetic Soft Robots for Active Drug Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Order-Disorder Balance in Silk-Elastin-like Polypeptides Determines Their Self-Assembly into Hydrogel Networks.ACS applied materials & interfaces · 2025Article
- Progress in Multiscale Modeling of Silk Materials.Biomacromolecules · 2024Review
- Modifying Naturally Occurring, Nonmammalian-Sourced Biopolymers for Biomedical Applications.ACS biomaterials science & engineering · 2024Review
- ForceGen: End-to-end de novo protein generation based on nonlinear mechanical unfolding responses using a language diffusion model.Science advances · 2024Article
- Inducing an LCST in hydrophilic polysaccharides via engineered macromolecular hydrophobicity.Scientific reports · 2023Article
- Generative design ofChem · 2023Article
- Silk chemistry and biomedical material designs.Nature reviews. Chemistry · 2023Review
- Scientometric Research on Trend Analysis of Nano-Based Sustained Drug Release Systems for Wound Healing.Pharmaceutics · 2023Article
- Genetically Engineered Viral Vectors and Organic-Based Non-Viral Nanocarriers for Drug Delivery Applications.Advanced healthcare materials · 2022Review
- Silk-Elastin-Like-Protein/Graphene-Oxide Composites for Dynamic Electronic Biomaterials.Macromolecular bioscience · 2022Article
- 3D Printing of Monolithic Proteinaceous Cantilevers Using Regenerated Silk Fibroin.Molecules (Basel, Switzerland) · 2022Article
- Fast and reversible crosslinking of a silk elastin-like polymer.Acta biomaterialia · 2022Article
- Charge-Modulated Accessibility of Tyrosine Residues for Silk-Elastin Copolymer Cross-Linking.Biomacromolecules · 2022Article
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Authors and funding
9 authors.
Funding
Abstract
Elastomeric, robust, and biocompatible hydrogels are rare, while the need for these types of biomaterials in biomedical-related uses remains high. Here, a new family of genetically engineered silk-elastin copolymers (SELPs) with encoded enzymatic crosslinking sites is developed for a new generation of stimuli-responsive yet robust hydrogels. Input into the designs is guided by simulation, and realized via genetic engineering strategies. The avoidance of gamma irradiation or chemical crosslinking during gel fabrication, in lieu of an enzymatic process, expands the versatility of these new gels for the incorporation of labile proteins and cells. In the present study, the new SELP hydrogels offers sequence dependent, reversible stimuli-responsive features. Their stiffness covers almost the full range of the elasticity of soft tissues. Further, physical modification of the silk domains provided a secondary control point to fine-tune mechanical stiffness while preserving stimuli-responsive features, with implications for a variety of biomedical materials and device needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.