ArticleCrystal growth & design2016
Why do Hydrates (Solvates) Form in Small Neutral Organic Molecules? Exploring the Crystal Form Landscapes of the Alkaloids Brucine and Strychnine.
Article in Crystal growth & design, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 42 citations in OpenAlex.
- Crystal engineering for poorly water-soluble drugs: From design to applications.Acta pharmaceutica Sinica. B · 2026Review
- Exploring the Solid-State Landscape of Carbamazepine during Dehydration: A Low Frequency Raman Spectroscopy Perspective.Pharmaceutics · 2023Article
- A data-driven and topological mapping approach for the a priori prediction of stable molecular crystalline hydrates.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Solid-State Forms of Koumine Hydrochloride: Phase Transformations and the Crystal Structure and Properties of the Stable Form.ACS omega · 2022Article
- Toward an Understanding of the Propensity for Crystalline Hydrate Formation by Molecular Compounds. Part 2.Crystal growth & design · 2021Article
- Challenges and opportunities of pharmaceutical cocrystals: a focused review on non-steroidal anti-inflammatory drugs.RSC medicinal chemistry · 2021Review
- Article
- Pharmaceutical Hydrates Analysis-Overview of Methods and Recent Advances.Pharmaceutics · 2020Review
- Supramolecular Organization of Nonstoichiometric Drug Hydrates: Dapsone.Frontiers in chemistry · 2018Article
- Experimental and Computational Hydrate Screening: Cytosine, 5-Flucytosine and Their Solid Solution.Crystal growth & design · 2017Article
- Why do Hydrates (Solvates) Form in Small Neutral Organic Molecules? Exploring the Crystal Form Landscapes of the Alkaloids Brucine and Strychnine.Crystal growth & design · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Computational methods were used to generate and explore the crystal structure landscapes of the two alkaloids strychnine and brucine. The computed structures were analyzed and rationalized by correlating the modelling results to a rich pool of available experimental data. Despite their structural similarity, the two compounds show marked differences in the formation of solid forms. For strychnine only one anhydrous form is reported in the literature and two new solvates from 1,4-dioxane were detected in the course of this work. In contrast, 22 solid forms are so far known to exist for brucine, comprising two anhydrates, four hydrates (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.