ArticleNeuropsychiatric disease and treatment2017
Clinical features of limbic encephalitis with LGI1 antibody.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 77 citations in OpenAlex.
- One Patient with 3 Antibody-Confirmed Neurological Autoimmune Syndromes: A Case Report and Review of the Literature.The American journal of case reports · 2025Review
- Anti-LGI1-antibody autoimmune encephalitis as a neurological paraneoplastic syndrome associated with gastrointestinal stromal tumour: a case report.Postepy psychiatrii neurologii · 2025Article
- Leucine-rich glioma-inactivated protein 1 antibody-positive limbic encephalitis in a patient with an early-stage asymptomatic breast cancer.BMJ case reports · 2025Article
- Article
- Rare mixed dementia: A case report.World journal of radiology · 2025Article
- Altered effective connectivity in leucine-rich glioma-inactivated 1 antibody encephalitis: a spectral dynamic causal modeling study.Psychoradiology · 2025Article
- Clinical features, cerebrospinal fluid changes, and prognosis in Chinese patients with autoimmune encephalitis.Acta neurologica Belgica · 2024Article
- Case report: Refractory focal motor seizure associated with cerebrospinal fluid neurochondrin antibody.Frontiers in immunology · 2024Article
- Decoding Dystonia in Autoimmune Disorders: A Scoping Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Neuropsychological and Structural Neuroimaging Outcomes in LGI1-Limbic Encephalitis: A Case Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2023Article
- Anti-leucine-rich glioma inactivated protein 1 encephalitis with sleep disturbance as the first symptom: A case report and review of literature.World journal of clinical cases · 2023Article
- Important Clues for the Diagnosis of Anti-LGI1-Antibody Autoimmune Encephalitis: A Case Report.Cureus · 2023Article
- Overlapping Autoimmune Neurological Syndrome: A Case Report of Triple-Positive Antibody.Cureus · 2022Article
- Diagnosis and Clinical Features in Autoimmune-Mediated Movement Disorders.Journal of movement disorders · 2022Article
- Confusion and Hallucination in a Geriatric Patient. Pitfalls of a Rare Differential: Case Report of an Anti-LGI1-Encephalitis.Clinical interventions in aging · 2022Article
- Altered Mental Status in the Emergency Department - When to Consider Anti-LGI-1 Encephalitis: Case Report.Clinical practice and cases in emergency medicine · 2021Article
- Morvan syndrome associated with LGI1 antibody: a case report.BMC neurology · 2021Article
- Clinical Features and Long-Term Outcomes of Anti-Leucine-Rich Glioma-Inactivated 1 Encephalitis: A Multi-Center Study.Neuropsychiatric disease and treatment · 2021Article
- Clinical Characteristics and Long-Term Prognosis of Anti-LGI1 Encephalitis: A Single-Center Cohort Study in Beijing, China.Frontiers in neurology · 2021Article
- Sleep Disturbances in Autoimmune Neurologic Diseases: Manifestation and Pathophysiology.Frontiers in neuroscience · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study was to analyze the clinical manifestation, course, evolution, image manifestation, and treatments of LGI1 limbic encephalitis (LE). PATIENTS AND
methodsStudies confirmed that LE with the complex antibody of voltage-gated potassium channels is LGI1 LE. Since then, LE cases have been reported. In this study, 10 typical LE cases were searched in PubMed. These cases and one additional case, which we reported herein, were retrospectively analyzed.
resultsAll the patients suffered from recent memory deterioration. The following cases were observed: eight with faciobrachial dystonic seizures (FBDS), six with different kinds of epileptic seizures (four complex partial seizures, one myoclonus seizure, and one generalized tonic-clonic seizure), four with FBDS and different kinds of epileptic seizures at the same time, five with mental disorders (one visual hallucination, one paranoia, one depression, one anxiety, and one dysphoria), five with hyponatremia, and two with sleep disorder. The brain MRI of nine patients revealed abnormalities in the mediotemporal lobe and the hippocampus. The LGI1 antibodies in the blood and/or cerebrospinal fluid (CSF) were positive. The content of the CSF protein of two patients increased slightly. The tumor marker of all the patients was normal, but capitate myxoma was detected in the combined pancreas duct of one patient. Gamma globulin and hormone treatments were administered to nine patients. Of these patients, six received a combination of antiepileptic drugs. The clinical symptoms of all the patients improved.
conclusionLGI1 LE is an autoimmune encephalitis whose clinical manifestations are memory deterioration, FBDS, epileptic seizure, mental disorders, and hyponatremia. Brain MRI shows that this autoimmune disease mainly involves the mediotemporal lobe and the hippocampus. This condition can also be manifested with other autoimmune encephalitis cases but can be rarely associated with tumors. After patients with LGI1 LE receive gamma globulin and hormone treatments, their clinical prognosis is good.
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