ArticleInternational journal of nanomedicine2017
Species-specific identification of collagen components in Colla corii asini using a nano-liquid chromatography tandem mass spectrometry proteomics approach.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.Chinese medicine · 2025Article
- Toxicokinetics of a Single Oral Dose of Aflatoxin BToxins · 2025Article
- Revealing the Transcriptional and Metabolic Characteristics of Sebocytes Based on the Donkey Cell Transcriptome Atlas.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Proteomic Analysis of Collagen: a Mass Spectrometry Approach to Material Identification of Shadow Puppet Cultural Relics.Applied biochemistry and biotechnology · 2024Article
- Elucidating the Role of Transcriptomic Networks and DNA Methylation in Collagen Deposition of Dezhou Donkey Skin.Animals : an open access journal from MDPI · 2024Article
- Blood-supplementing effect of low molecular weight peptides of E-Jiao on chemotherapy-induced myelosuppression: evaluation of pharmacological activity and identification of bioactive peptides releasedFrontiers in pharmacology · 2024Article
- A Synergetic Strategy for Brand Characterization of Colla Corii Asini (Ejiao) by LIBS and NIR Combined with Partial Least Squares Discriminant Analysis.Molecules (Basel, Switzerland) · 2023Article
- Feral pharmaceuticalization-Biomedical uses of animal life in light of the global donkey hide trade.BioSocieties · 2023Article
- The effects of E'Jiao on body composition, bone marrow adiposity and skeletal redox status in ovariectomised rats.International journal of medical sciences · 2023Article
- Qualitative and Quantitative Analysis of Ejiao-Related Animal Gelatins through Peptide Markers Using LC-QTOF-MS/MS and Scheduled Multiple Reaction Monitoring (MRM) by LC-QQQ-MS/MS.Molecules (Basel, Switzerland) · 2022Article
- A Strategy for Rapid Discovery of Marker Peptides Associated with Fibrinolytic Efficacy ofMolecules (Basel, Switzerland) · 2022Article
- Species-specific identification of donkey-hide gelatin and its adulterants using marker peptides.PloS one · 2022Article
- A Species-Specific Strategy for the Identification of HemocoagulaseFrontiers in molecular biosciences · 2022Article
- [Determination of donkey skin ingredients in Asini Corii Colla by ultra-high performance liquid chromatography-tandem mass spectrometry].Se pu = Chinese journal of chromatography · 2021Article
- Marker peptide screening and species-specific authentication of Pheretima using proteomics.Analytical and bioanalytical chemistry · 2021Article
- Collagen derived species-specific peptides for distinguishing donkey-hide gelatin (Chinese herbal medicines · 2021Article
- Specific, sensitive and rapid authentication of donkey-hide gelatine (Journal of food science and technology · 2020Article
- The Potential for New Donkey Farming Systems to Supply the Growing Demand for Hides.Animals : an open access journal from MDPI · 2020Article
- Differential proteomics for studying action mechanisms of traditional Chinese medicines.Chinese medicine · 2019Review
- A rapid and simple UPLC-MS/MS method using collagen marker peptides for identification of porcine gelatin.RSC advances · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colla corii asini (CCA) is a protein-based traditional Chinese medicine made from donkey skins. Because it has the ability to nourish blood, its demand is increasing rapidly. The shortage of donkey skins increases the risk of the adulteration of CCA products with other animal skins. To ensure the drug efficacy and safety of CCA products, a proteomics technique was applied to reveal proteins in the skins of donkey, horse, cattle, and pig. Species-specific peptides for each animal species were predicted using bioinformatics, and their presence in the skins and gelatin samples was examined by nano-liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS). One unique marker peptide for each animal species was selected to develop an LC-MS/MS multiple reaction monitoring method. The capability of this method to identify donkey, horse, cattle, and pig materials was demonstrated by analyzing in-house-made donkey gelatins containing different amounts of other animal skins and commercial CCA products. The adulteration of non-donkey species could be sensitively detected at a low level of 0.5%. Hybrid animals, such as mules and hinnies, were also differentiated from donkeys. We provide a practical tool for the quality control of CCA products. The strategy can also be used to study other important traditional Chinese medicines which contain animal proteins.
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