ArticleInternational journal of obesity (2005)2017
Exercise training improves fat metabolism independent of total energy expenditure in sedentary overweight men, but does not restore lean metabolic phenotype.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association Between Adipose Tissue Characteristics and Metabolic Flexibility in Humans: A Systematic Review.Frontiers in nutrition · 2021Pooled it
- Successfully Reducing Sitting Time Can Improve Metabolic Flexibility.Scandinavian journal of medicine & science in sports · 2025Trial
- Lipid Metabolism Links Nutrient-Exercise Timing to Insulin Sensitivity in Men Classified as Overweight or Obese.The Journal of clinical endocrinology and metabolism · 2020Trial
- The energy expenditure and substrate oxidation of treadmill running and cycle ergometer exercise in normal-weight and obese men.BMC sports science, medicine & rehabilitation · 2026Article
- Sex- and endurance training-mediated cardiovascular protection through lipids during exercise.Trends in endocrinology and metabolism: TEM · 2025Review
- Unraveling the Therapeutic Potential of Muscle Strengthening Exercises for Reversing Diabetes Mellitus.Current diabetes reviews · 2025Review
- The role of physical activity in the regulation of body weight: The overlooked contribution of light physical activity and sedentary behaviors.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Review
- Article
- Insulin and cancer: a tangled web.The Biochemical journal · 2022Review
- Physiology of physical inactivity, sedentary behaviours and non-exercise activity: insights from the space bedrest model.The Journal of physiology · 2022Review
- Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.Seminars in cell & developmental biology · 2022Review
- Physical activity and fitness in childhood cancer survivors: a scoping review.Aging and cancer · 2021Article
- Knockdown of lncRNA TTTY15 alleviates ischemia/reperfusion-induced inflammation and apoptosis of PC12 cells by targeting miR-766-5p.Experimental and therapeutic medicine · 2021Article
- Is Being Physically Active Enough to Be Metabolically Healthy? The Key Role of Sedentary Behavior.Diabetes care · 2021Article
- Tuning fatty acid oxidation in skeletal muscle with dietary fat and exercise.Nature reviews. Endocrinology · 2020Review
- Exercise Effects on Mitochondrial Function and Lipid Metabolism during Energy Balance.Medicine and science in sports and exercise · 2020Article
- Substrate utilization and metabolic profile in response to overfeeding with a high-fat diet in South Asian and white men: a sedentary lifestyle study.International journal of obesity (2005) · 2020Article
- Review
- Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight.Frontiers in physiology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundObesity is a dietary fat storage disease. Although exercise prevents weight gain, effects of chronic training on dietary fat oxidation remains understudied in overweight adults.
objectiveWe tested whether 2 months of training at current guidelines increase dietary fat oxidation in sedentary overweight adults like in sedentary lean adults.
designSedentary lean (n=10) and overweight (n=9) men trained on a cycle ergometer at 50% VO
resultsConversely to lean subjects, TEE and AEE did not increase in overweight participants due to a spontaneous decrease in non-training AEE. Despite this compensatory behavior, aerobic fitness, insulin sensitivity and fat oxidation were improved by exercise training. The latter was not explained by changes in dietary fat trafficking but more likely by a coordinated response at the muscle level enhancing fat uptake, acylation and oxidation (FABPpm, CD36, FATP1, ACSL1, CPT1, mtGPAT). ACSL1 fold change positively correlated with total fasting (R
conclusionIndependent of energy balance and TEE, exercise training at current recommendations improved fitness and fat oxidation in overweight adults. However the improved metabolic phenotype of overweight adults was not as healthy as the one of their lean counterparts before the 2-month training, likely due to the spontaneous reduction in non-training AEE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.