Evidence map›Paper›PMID 28669988›Full record

Observational studyInternational journal of obesity (2005)2017

Impairment of body mass reduction-associated activation of brown/beige adipose tissue in patients with type 2 diabetes mellitus.

S Rodovalho, B Rachid, J C De-Lima-Junior, S van de Sande-Lee, J Morari, H M Carvalho, B J Amorim, A J Tincani, E Chaim, J C Pareja and 5 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. DUODENAL-JEJUNAL BYPASS REDUCES LIPID ACCUMULATION IN THE BROWN ADIPOSE TISSUE OF HYPOTHALAMIC OBESE RATS.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2020
    Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 3 countries.

S RodovalhoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
B RachidLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
J C De-Lima-JuniorLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
S van de Sande-LeeLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
J MorariLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
H M CarvalhoUniversity of Campinas, Campinas, Brazil.
B J AmorimDivision of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil.
A J TincaniDepartment of Surgery, University of Campinas, Campinas, Brazil.
E ChaimDepartment of Surgery, University of Campinas, Campinas, Brazil.
J C ParejaDepartment of Surgery, University of Campinas, Campinas, Brazil.
M J SaadLaboratory of Experimental Endocrinology, Department of Internal Medicine, University of Campinas, Campinas, Brazil.
F FolliDepartment of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-9824-5222
C D RamosDivision of Nuclear Medicine, Department of Radiology, University of Campinas, Campinas, Brazil.
B GelonezeLaboratory of Investigation in Metabolism and Diabetes, University of Campinas, Campinas, Brazil.ORCID 0000-0002-0557-4578
L A VellosoLaboratory of Cell Signaling, Department of Internal Medicine, University of Campinas, Campinas, Brazil.ORCID 0000-0002-4806-7218
Universidade Estadual de Campinas (UNICAMP) · BRThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgrounds/Objectives:The activity of brown/beige adipose tissue (B/BAT) is inversely proportional to body adiposity. Studies have shown that obese subjects submitted to distinct approaches aimed at reducing body mass present an increase of B/BAT activation. However, it is unknown if this beneficial effect of body mass reduction applies to patients with type 2 diabetes mellitus. In this study, we evaluated the impact of massive body mass reduction obtained as a consequence of bariatric surgery in the cold-induced activation of B/BAT in obese non-diabetic (OND) and obese diabetic (OD) subjects. SUBJECTS/

methodsThis is an observational study. Fourteen OND, 14 OD and 11 subjects were included in the study. All obese subjects were submitted to Roux-in-Y gastric bypass and measurements were performed before and 8 months after surgery. B/BAT was evaluated by (

resultsBefore surgery, mean B/BAT activity and the expression of signature transcripts were similar between OND and OD groups. Eight months after surgery, body mass reduction was similar between the obese groups. Nevertheless, the activity of B/BAT was increased in OND and unchanged in OD subjects. This effect was correlated with a more pronounced improvement of insulin resistance, as evaluated by the hyperinsulinemic, euglycemic clamp, in OND subjects as compared with OD subjects.

conclusionsBody mass reduction has a more efficient effect to induce the activation of B/BAT in non-diabetic than in diabetic subjects. This effect is accompanied by more pronounced insulin sensitivity and serine 473 phosphorylation of Akt in B/BAT of non-diabetic than in diabetic subjects.

Indexed as

Gastric BypassAdaptation, PhysiologicalAdipose Tissue, BeigeAdipose Tissue, BrownAdultBody Mass IndexDiabetes Mellitus, Type 2FemaleFluorodeoxyglucose F18HumansInsulin ResistanceObesity, MorbidPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTreatment OutcomeWeight LossFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID28669988
OpenAlexW2725385568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.