Evidence map›Paper›PMID 28669939›Full record

ArticleEnvironmental health perspectives2017

Major Limitations in Using Element Concentrations in Hair as Biomarkers of Exposure to Toxic and Essential Trace Elements in Children.

Helena Skröder, Maria Kippler, Barbro Nermell, Fahmida Tofail, Michael Levi, Syed Moshfiqur Rahman, Rubhana Raqib, Marie Vahter

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Article in Environmental health perspectives, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  17. Arsenic exposure and increasedRedox biochemistry and chemistry · 2023
    Article
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  20. Levels of Toxic and Essential Elements and Associated Factors in the Hair of Japanese Young Children.International journal of environmental research and public health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helena SkröderUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Maria KipplerUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Barbro NermellUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Fahmida TofailInternational Center for Diarrheal Disease Research, Dhaka, Bangladesh.
Michael LeviUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Syed Moshfiqur RahmanUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Rubhana RaqibInternational Center for Diarrheal Disease Research, Dhaka, Bangladesh.
Marie VahterUnit of Metals and Health, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHair is a commonly used exposure biomarker for metals and other trace elements, but concern has been raised regarding its appropriateness for assessing the internal dose.

objectivesThe aim of the present study was to evaluate children's hair as biomarker of internal dose for toxic (As, Mn, Cd, Pb) and essential elements (Mg, Ca, Fe, Co, Cu, Zn, Se, Mo).

methodsIn 207 children (9-10 years of age), originating from a population-based cohort in rural Bangladesh, we measured concentrations of the selected elements in hair ( closest to the scalp) using ICP-MS. We compared these with previously measured concentrations in erythrocytes, urine, and water. For a subset of children (n=19), we analyzed four consecutive 2 cm pieces of hair.

resultsThere were strong associations between hair As and the other biomarkers (erythrocytes:

conclusionsHair was found to be a useful exposure biomarker of absorbed As and Se only. Of all measured elements, hair Mn seemed the least reflective of internal dose. https://doi.org/10.1289/EHP1239.

Indexed as

BangladeshBiomarkersChildEnvironmental ExposureEnvironmental PollutantsFemaleHairHumansMaleScalpTrace ElementsBiomarkersEnvironmental PollutantsTrace Elements

Identifiers

PMID28669939
PMCPMC5743543

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.